The Library
A mathematical model for the treatment of AIDS-related Kaposi's sarcoma
Tools
Szomolay, Barbara and Lungu, Edward M. (2014) A mathematical model for the treatment of AIDS-related Kaposi's sarcoma. Journal of Biological Systems, Volume 22 (Number 3). pp. 495-522. doi:10.1142/S0218339014500247 ISSN 0218-3390.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1142/S0218339014500247
Abstract
We formulate a mathematical model to study the dynamics of HIV-1 related Kaposi's Sarcoma (KS) pathogenesis. KS progression is modeled as a dual process involving the primary infection of B cells, which sustains HHV-8 replication and the secondary infection of progenitor cells by HHV-8, which sustains the KS cell replication. We incorporate the pharmacodynamics of highly active antiretroviral therapy (HAART), or combination therapy (HAART plus KS therapy) and consider how each treatment strategy alters the disease progression. Our results indicate that administration of HAART to individuals co-infected with the HIV-1 and HHV-8 viruses can greatly amplify the therapeutic response of low-dose KS therapies. We have found that adherence levels above 85% can significantly reduce the risk of KS and HIV for a treatment periods under 1 year. For longer treatment periods, however, at least 90% adherence level is recommended.
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||||||||
Journal or Publication Title: | Journal of Biological Systems | ||||||||||
Publisher: | World Scientific Publishing Co. Pte. Ltd. | ||||||||||
ISSN: | 0218-3390 | ||||||||||
Official Date: | September 2014 | ||||||||||
Dates: |
|
||||||||||
Volume: | Volume 22 | ||||||||||
Number: | Number 3 | ||||||||||
Page Range: | pp. 495-522 | ||||||||||
DOI: | 10.1142/S0218339014500247 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Adapted As: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |