Bilateral intrahippocampal NAC(61-95) effects on behavior and moderation with L-NAME treatment
O'Hare, Eugene, Elliott, Jennifer J., Hobson, Peter, O'Mara, Shane M., Spanswick, David and Kim, Eun-Mee. (2010) Bilateral intrahippocampal NAC(61-95) effects on behavior and moderation with L-NAME treatment. Neuroscience Research, Vol.66 (No.2). pp. 213-218. ISSN 0168-0102Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.neures.2009.11.002
Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein. This study evaluated the effect of N-(omega)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, on the behavior of rats bilaterally injected into the CA3 area of the dorsal hippocampus with aggregated NAC(61-95). Twenty-four male Sprague-Dawley rats were trained to respond under an alternating-lever cyclic-ratio (ALCR) operant schedule. When responding was stable, 12 rats were injected bilaterally into the CA3 area of the hippocampus with aggregated NAC(61-95) (5 mu l per side; concentration 10(-4) M), the remaining 12 rats were similarly injected with sterile water (SW), six of the NAC(61-95) injected rats and six of the SW injected rats were treated for 90 days post-injections with 0.05 mg/ml L-NAME in drinking water available ad libitum. Treatment with L-NAME alleviated NAC(61-95)-induced behavioral deficits, indicated through the measurement of lever switching errors and incorrect lever perseverations under the ALCR schedule, and reduced the number of activated astrocytes proximal to the injection sites. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
|Divisions:||Faculty of Medicine > Warwick Medical School > Translational & Systems Medicine > Metabolic and Vascular Health
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Neuroscience Research|
|Publisher:||Elsevier Ireland Ltd|
|Official Date:||February 2010|
|Number of Pages:||6|
|Page Range:||pp. 213-218|
|Access rights to Published version:||Restricted or Subscription Access|
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