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A G4·K+Hydrogel stabilized by an anion
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Peters, Gretchen Marie, Skala, Luke P., Plank, Taylor N., Hyman, Brooke J., Reddy, G. N. Manjunatha, Marsh, Andrew, Brown, Steven P. and Davis, Jeffery T. (2014) A G4·K+Hydrogel stabilized by an anion. Journal of the American Chemical Society, 136 (36). pp. 12596-12599. doi:10.1021/ja507506c
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Official URL: http://dx.doi.org/10.1021/ja507506c
Abstract
Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)4. This ratio of borate anion to ligand is crucial for gelation as it links two molecules of 1, which facilitates cation-templated assembly of G4·K+ quartets. The guanosine–borate (GB) hydrogel, which was characterized by cryogenic transmission electron microscopy and circular dichroism and 11B magic-angle-spinning NMR spectroscopy, is stable in water that contains physiologically relevant concentrations of K+. Furthermore, non-covalent interactions, such as electrostatics, π-stacking, and hydrogen bonding, enable the incorporation of a cationic dye and nucleosides into the GB hydrogel.
| Item Type: | Journal Article | |||||||||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||||||||||||||||||||
| Divisions: | Faculty of Science > Chemistry Faculty of Science > Physics |
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| Library of Congress Subject Headings (LCSH): | Supramolecular chemistry, Colloids, Anions | |||||||||||||||||||||||||||
| Journal or Publication Title: | Journal of the American Chemical Society | |||||||||||||||||||||||||||
| Publisher: | American Chemical Society | |||||||||||||||||||||||||||
| ISSN: | 0002-7863 | |||||||||||||||||||||||||||
| Official Date: | 10 September 2014 | |||||||||||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 19 October 2017 | |||||||||||||||||||||||||||
| Volume: | 136 | |||||||||||||||||||||||||||
| Number: | 36 | |||||||||||||||||||||||||||
| Page Range: | pp. 12596-12599 | |||||||||||||||||||||||||||
| DOI: | 10.1021/ja507506c | |||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||
| Access rights to Published version: | Open Access | |||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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