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A G4·K+Hydrogel stabilized by an anion

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Peters, Gretchen Marie, Skala, Luke P., Plank, Taylor N., Hyman, Brooke J., Reddy, G. N. Manjunatha, Marsh, Andrew, Brown, Steven P. and Davis, Jeffery T. (2014) A G4·K+Hydrogel stabilized by an anion. Journal of the American Chemical Society, 136 (36). pp. 12596-12599. doi:10.1021/ja507506c

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Official URL: http://dx.doi.org/10.1021/ja507506c

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Abstract

Supramolecular hydrogels derived from natural products have promising applications in diagnostics, drug delivery, and tissue engineering. We studied the formation of a long-lived hydrogel made by mixing guanosine (G, 1) with 0.5 equiv of KB(OH)4. This ratio of borate anion to ligand is crucial for gelation as it links two molecules of 1, which facilitates cation-templated assembly of G4·K+ quartets. The guanosine–borate (GB) hydrogel, which was characterized by cryogenic transmission electron microscopy and circular dichroism and 11B magic-angle-spinning NMR spectroscopy, is stable in water that contains physiologically relevant concentrations of K+. Furthermore, non-covalent interactions, such as electrostatics, π-stacking, and hydrogen bonding, enable the incorporation of a cationic dye and nucleosides into the GB hydrogel.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Chemistry
Faculty of Science > Physics
Library of Congress Subject Headings (LCSH): Supramolecular chemistry, Colloids, Anions
Journal or Publication Title: Journal of the American Chemical Society
Publisher: American Chemical Society
ISSN: 0002-7863
Official Date: 10 September 2014
Dates:
DateEvent
10 September 2014Published
26 August 2014Accepted
23 July 2014Submitted
Volume: 136
Number: 36
Page Range: pp. 12596-12599
DOI: 10.1021/ja507506c
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
DE-FG01-98ER14888U.S. Department of Energyhttp://dx.doi.org/10.13039/100000015
EP/K003674/1Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
GAANN FellowshipU.S. Department of Educationhttp://dx.doi.org/10.13039/100000138
UNSPECIFIEDBiotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
UNSPECIFIEDEuropean Regional Development Fundhttp://dx.doi.org/10.13039/501100008530
UNSPECIFIEDBirmingham Science CityUNSPECIFIED
UNSPECIFIEDAdvantage West Midlands (AWM)UNSPECIFIED

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