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Effect of curcumin on lateral diffusion of phosphatidylcholines in saturated and unsaturated bilayers
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Filippov, Andrei V., Kotenkov, Sergey A., Munavirov, Bulat and Antzutkin, Oleg N. (2014) Effect of curcumin on lateral diffusion of phosphatidylcholines in saturated and unsaturated bilayers. Langmuir, Volume 30 (Number 35). pp. 10686-10690. doi:10.1021/la502338c ISSN 0743-7463.
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Official URL: http://dx.doi.org/10.1021/la502338c
Abstract
Curcumin, a dietary polyphenol, is a natural spice with preventive and therapeutic potential for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. Curcumin possesses a spectrum of antioxidant, anti-inflammatory, anticarcinogenic, and antimutagenic properties. Because of this broad spectrum of pharmacological activity, it has been suggested that, like cholesterol, curcumin exerts its effect on a rather basic biological level, such as on lipid bilayers of biomembranes. The effect of curcumin on translational mobility of lipids in biomembranes has not yet been studied. In this work, we used 1H NMR diffusometry to explore lateral diffusion in planar-oriented bilayers of dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) at curcumin concentrations of up to 40 mol % and in the temperature range of 298–333 K. The presence of curcumin at much lower concentrations (∼7 mol %) leads to a decrease in the lateral diffusion coefficient of DOPC by a factor of 1.3 at lower temperatures and by a factor of 1.14 at higher temperatures. For DMPC, the diffusion coefficient decreases by a factor of 1.5 at lower temperatures and by a factor of 1.2 at higher temperatures. Further increasing the curcumin concentration has no effect. Comparison with cholesterol showed that curcumin and cholesterol influence lateral diffusion of lipids differently. The effect of curcumin is determined by its solubility in lipid bilayers, which is as low as 10 mol % that is much less than that of cholesteroĺs 66 mol %.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||||
Journal or Publication Title: | Langmuir | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 0743-7463 | ||||||||
Official Date: | 9 September 2014 | ||||||||
Dates: |
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Volume: | Volume 30 | ||||||||
Number: | Number 35 | ||||||||
Page Range: | pp. 10686-10690 | ||||||||
DOI: | 10.1021/la502338c | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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