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A case-control study to assess the impact of mammographic density on breast cancer risk in women aged 40-49 at intermediate familial risk

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Assi, Valentina, Massat, Nathalie J., Thomas, Susan, MacKay, James, Warwick, Jane, Kataoka, Masako, Warsi, Iqbal, Brentnall, Adam, Warren, Ruth and Duffy, Stephen W. (2015) A case-control study to assess the impact of mammographic density on breast cancer risk in women aged 40-49 at intermediate familial risk. International Journal of Cancer, 136 (10). pp. 2378-2387. doi:10.1002/ijc.29275

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Official URL: http://dx.doi.org/10.1002/ijc.29275

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Abstract

Mammographic density is a strong risk factor for breast cancer, but its potential application in risk management is not clear, partly due to uncertainties about its interaction with other breast cancer risk factors.

We aimed to quantify the impact of mammographic density on breast cancer risk in women aged 40-

49 at intermediate familial risk of breast cancer (average lifetime risk of 23%), in particular in premenopausal women, and to investigate its relationship with other breast cancer risk factors in this population.

We present the results from a case-control study nested with the FH01 cohort study of 6,710 women mostly aged 40-49 at intermediate familial risk of breast cancer. One hundred and three cases of breast cancer were age-matched to one or two controls. Density was measured by semi-automated interactive thresholding.

Absolute density, but not percent density, was a significant risk factor for breast cancer in this population after adjusting for area of non-dense tissue (OR per 10 cm2 = 1.07, 95% CI 1.00-1.15, p=0.04). The effect was stronger in premenopausal women, who made up the majority of the study population. Absolute density remained a significant predictor of breast cancer risk after adjusting for age at menarche, age at first live birth, parity, past or present hormone replacement therapy, and the Tyrer-Cuzick 10-year relative risk estimate of breast cancer.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: International Journal of Cancer
Publisher: John Wiley & Sons Ltd.
ISSN: 0020-7136
Official Date: 15 May 2015
Dates:
DateEvent
15 May 2015Published
21 October 2014Available
12 September 2014Accepted
Volume: 136
Number: 10
Page Range: pp. 2378-2387
DOI: 10.1002/ijc.29275
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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