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A case-control study to assess the impact of mammographic density on breast cancer risk in women aged 40-49 at intermediate familial risk
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Assi, Valentina, Massat, Nathalie J., Thomas, Susan, MacKay, James, Warwick, Jane, Kataoka, Masako, Warsi, Iqbal, Brentnall, Adam, Warren, Ruth and Duffy, Stephen W. (2015) A case-control study to assess the impact of mammographic density on breast cancer risk in women aged 40-49 at intermediate familial risk. International Journal of Cancer, 136 (10). pp. 2378-2387. doi:10.1002/ijc.29275
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Official URL: http://dx.doi.org/10.1002/ijc.29275
Abstract
Mammographic density is a strong risk factor for breast cancer, but its potential application in risk management is not clear, partly due to uncertainties about its interaction with other breast cancer risk factors.
We aimed to quantify the impact of mammographic density on breast cancer risk in women aged 40-
49 at intermediate familial risk of breast cancer (average lifetime risk of 23%), in particular in premenopausal women, and to investigate its relationship with other breast cancer risk factors in this population.
We present the results from a case-control study nested with the FH01 cohort study of 6,710 women mostly aged 40-49 at intermediate familial risk of breast cancer. One hundred and three cases of breast cancer were age-matched to one or two controls. Density was measured by semi-automated interactive thresholding.
Absolute density, but not percent density, was a significant risk factor for breast cancer in this population after adjusting for area of non-dense tissue (OR per 10 cm2 = 1.07, 95% CI 1.00-1.15, p=0.04). The effect was stronger in premenopausal women, who made up the majority of the study population. Absolute density remained a significant predictor of breast cancer risk after adjusting for age at menarche, age at first live birth, parity, past or present hormone replacement therapy, and the Tyrer-Cuzick 10-year relative risk estimate of breast cancer.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | International Journal of Cancer | ||||||||
| Publisher: | John Wiley & Sons Ltd. | ||||||||
| ISSN: | 0020-7136 | ||||||||
| Official Date: | 15 May 2015 | ||||||||
| Dates: |
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| Volume: | 136 | ||||||||
| Number: | 10 | ||||||||
| Page Range: | pp. 2378-2387 | ||||||||
| DOI: | 10.1002/ijc.29275 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
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