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An optical-manipulation technique for cells in physiological flows
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Zhang, Hu, Chen, Neng H., El Haj, Alicia J. and Liu, Kuo-Kang. (2010) An optical-manipulation technique for cells in physiological flows. Journal of Biological Physics, Vol.36 (No.2). pp. 135-143. ISSN 0092-0606
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Official URL: http://dx.doi.org/10.1007/s10867-009-9176-6
Abstract
We have developed a technique to manipulate human red blood cells (RBCs) in hydrodynamic flows. This method applies optical tweezers to trap and move microbead-attached RBCs in a liquid medium at various speeds, while it significantly minimizes laser heating and photon-induced stress for normal operation with laser-trapped cells. Computational fluid dynamics is applied to simulate flow-induced shear stress over the cell membrane and to correlate quantitatively the forces with the cell deformations. RBCs can be manipulated under physiological conditions by this approach, which may open an avenue to design principles for the next generation of cell sorting and delivery.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QP Physiology T Technology > TA Engineering (General). Civil engineering (General) T Technology > TK Electrical engineering. Electronics Nuclear engineering |
| Divisions: | Faculty of Science > Engineering |
| Library of Congress Subject Headings (LCSH): | Optical tweezers, Erythrocytes, Cytology -- Technique, Hydrodynamics, Computational fluid dynamics, Erythrocytes -- Deformability |
| Journal or Publication Title: | Journal of Biological Physics |
| Publisher: | Springer Netherlands |
| ISSN: | 0092-0606 |
| Date: | March 2010 |
| Volume: | Vol.36 |
| Number: | No.2 |
| Number of Pages: | 9 |
| Page Range: | pp. 135-143 |
| Identification Number: | 10.1007/s10867-009-9176-6 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Engineering and Physical Sciences Research Council (EPSRC) |
| Grant number: | BB/D014786/1 (BBSRC, EPSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/6373 |
Data sourced from Thomson Reuters' Web of Knowledge
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