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Drug conjugation to cyclic peptide-polymer self-assembling nanotubes
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Blunden , Bianca M., Chapman, Robert, Danial, Maarten, Lu, Hongxu, Jolliffe, Katrina A., Perrier, Sébastien and Stenzel, Martina H. (2014) Drug conjugation to cyclic peptide-polymer self-assembling nanotubes. Chemistry - A European Journal, Volume 20 (Number 40). pp. 12745-12749. doi:10.1002/chem.201403130 ISSN 0947-6539.
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Official URL: http://dx.doi.org/10.1002/chem.201403130
Abstract
We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200–500 nm) led to structures exhibiting high activity against cancer cells.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| Journal or Publication Title: | Chemistry - A European Journal | ||||||||
| Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||
| ISSN: | 0947-6539 | ||||||||
| Official Date: | 26 September 2014 | ||||||||
| Dates: |
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| Volume: | Volume 20 | ||||||||
| Number: | Number 40 | ||||||||
| Page Range: | pp. 12745-12749 | ||||||||
| DOI: | 10.1002/chem.201403130 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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