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Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines
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Bisset, Alexander A., Dishington, Allan, Jones, Teyrnon C., Clarkson, Guy J. and Wills, Martin (2014) Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines. Tetrahedron, 70 (40). pp. 7207-7220. doi:10.1016/j.tet.2014.06.046 ISSN 0040-4020 .
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WRAP_9574780-ch-280915-tet-d-14-00753_wills_corrected_june_2014 %281%29.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (1605Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.tet.2014.06.046
Abstract
The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Organic compounds -- Synthesis, Hydroxypyridones -- Sythesis | ||||||||||
Journal or Publication Title: | Tetrahedron | ||||||||||
Publisher: | Pergamon | ||||||||||
ISSN: | 0040-4020 | ||||||||||
Official Date: | October 2014 | ||||||||||
Dates: |
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Volume: | 70 | ||||||||||
Number: | 40 | ||||||||||
Number of Pages: | 14 | ||||||||||
Page Range: | pp. 7207-7220 | ||||||||||
DOI: | 10.1016/j.tet.2014.06.046 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 28 December 2015 | ||||||||||
Date of first compliant Open Access: | 28 December 2015 | ||||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), AstraZeneca (Firm) | ||||||||||
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