Bisset, Alexander A., Dishington, Allan, Jones, Teyrnon C., Clarkson, Guy J. and Wills, Martin (2014) Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines. Tetrahedron, 70 (40). pp. 7207-7220. doi:10.1016/j.tet.2014.06.046

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Abstract

The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH):	Organic compounds -- Synthesis, Hydroxypyridones -- Sythesis
Journal or Publication Title:	Tetrahedron
Publisher:	Pergamon
ISSN:	0040-4020
Official Date:	October 2014
Dates:	Date Event October 2014 Published 19 June 2014 Available 13 June 2014 Accepted 22 April 2014 Submitted
Volume:	70
Number:	40
Number of Pages:	14
Page Range:	pp. 7207-7220
DOI:	10.1016/j.tet.2014.06.046
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), AstraZeneca (Firm)
Related URLs:	Related dataset

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