The Library
Thermal gating in lipid membranes using thermoresponsive cyclic peptide–polymer conjugates
Tools
Tools
Tools
Danial, Maarten, Tran, Carmen M.-N., Jolliffe, Katrina A. and Perrier, Sébastien (2014) Thermal gating in lipid membranes using thermoresponsive cyclic peptide–polymer conjugates. Journal of the American Chemical Society, Volume 136 (Number 22). pp. 8018-8026. doi:10.1021/ja5024699 ISSN 0002-7863.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1021/ja5024699
Abstract
The partition and self-assembly of a new generation of cyclic peptide–polymer conjugates into well-defined phospholipid trans-bilayer channels is presented. By varying the structural parameters of the cyclic peptide–polymer conjugates through the ligation of hydrophobic and hydrophilic polymers, both the structure of the artificial channels using large unilamellar vesicle assays and the structural parameters required for phospholipid bilayer partitioning are elucidated. In addition, temperature was used as an external stimulus for the modulation of transbilayer channel formation without requiring the redesign and synthesis of the cyclic peptide core. The thermoresponsive character of the cyclic peptide–polymer conjugates lays the foundation for on-demand control over phospholipid transmembrane transport, which could lead to viable alternatives to current transport systems that traditionally rely on endocytic pathways.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
| Journal or Publication Title: | Journal of the American Chemical Society | ||||||
| Publisher: | American Chemical Society | ||||||
| ISSN: | 0002-7863 | ||||||
| Official Date: | 9 May 2014 | ||||||
| Dates: |
|
||||||
| Volume: | Volume 136 | ||||||
| Number: | Number 22 | ||||||
| Page Range: | pp. 8018-8026 | ||||||
| DOI: | 10.1021/ja5024699 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
