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The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity

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Finer, Sarah, Saravanan, Ponnusamy, Hitman, G. and Yajnik, Chittaranjan S. (2014) The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. Diabetic Medicine, Volume 31 (Number 3). pp. 263-272. doi:10.1111/dme.12390

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Official URL: http://dx.doi.org/10.1111/dme.12390

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Abstract

Vitamin B12 deficiency is common in certain populations, such as in India, where there is also a rising prevalence of Type 2 diabetes, obesity and their complications. Human cohorts and animal models provide compelling data suggesting the role of the one-carbon cycle in modulating the risk of diabetes and adiposity via developmental programming. Early mechanistic studies in animals suggest that alterations to the cellular provision of methyl groups (via the one-carbon cycle) in early developmental life may disrupt DNA methylation and induce future adverse phenotypic changes. Furthermore, replacement of micronutrient deficits at suitable developmental stages may modulate this risk. Current human studies are limited by a range of factors, including the accuracy and availability of methods to measure nutritional components in the one-carbon cycle, and whether its disruptions exert tissue-specific effects. A greater understanding of the causal and mechanistic role of the one-carbon cycle is hoped to generate substantial insights into its role in the developmental origins of complex metabolic diseases and the potential of targeted and population-wide prevention strategies.

Item Type: Journal Article
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: Diabetic Medicine
Publisher: Blackwell
ISSN: 0742-3071
Official Date: March 2014
Dates:
DateEvent
March 2014Published
16 February 2014Available
12 December 2013Accepted
15 November 2013Submitted
Volume: Volume 31
Number: Number 3
Page Range: pp. 263-272
DOI: 10.1111/dme.12390
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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