Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

The role of iron in neurodegenerative disorders : insights and opportunities with synchrotron light

Tools
- Tools
+ Tools

Collingwood, Joanna F. and Davidson, Mark R. (2014) The role of iron in neurodegenerative disorders : insights and opportunities with synchrotron light. Frontiers in Pharmacology, Volume 5 . Article number 191. doi:10.3389/fphar.2014.00191 ISSN 1663-9812.

[img]
Preview
PDF
WRAP_Collingwood_fphar-05-00191.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution.

Download (2758Kb) | Preview
Official URL: http://dx.doi.org/10.3389/fphar.2014.00191

Request Changes to record.

Abstract

There is evidence for iron dysregulation in many forms of disease, including a broad spectrum of neurodegenerative disorders. In order to advance our understanding of the pathophysiological role of iron, it is helpful to be able to determine in detail the distribution of iron as it relates to metabolites, proteins, cells, and tissues, the chemical state and local environment of iron, and its relationship with other metal elements. Synchrotron light sources, providing primarily X-ray beams accompanied by access to longer wavelengths such as infra-red, are an outstanding tool for multi-modal non-destructive analysis of iron in these systems. The micro- and nano-focused X-ray beams that are generated at synchrotron facilities enable measurement of iron and other transition metal elements to be performed with outstanding analytic sensitivity and specificity. Recent developments have increased the scope for methods such as X-ray fluorescence mapping to be used quantitatively rather than semi-quantitatively. Burgeoning interest, coupled with technical advances and beamline development at synchrotron facilities, has led to substantial improvements in resources and methodologies in the field over the past decade. In this paper we will consider how the field has evolved with regard to the study of iron in proteins, cells, and brain tissue, and identify challenges in sample preparation and analysis. Selected examples will be used to illustrate the contribution, and future potential, of synchrotron X-ray analysis for the characterization of iron in model systems exhibiting iron dysregulation, and for human cases of neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH): Iron -- Analysis, Iron in the body, Nervous system -- Degeneration, Synchrotrons
Journal or Publication Title: Frontiers in Pharmacology
Publisher: Frontiers Research Foundation
ISSN: 1663-9812
Official Date: 19 August 2014
Dates:
DateEvent
19 August 2014Published
25 July 2014Accepted
18 May 2014Submitted
Volume: Volume 5
Article Number: Article number 191
DOI: 10.3389/fphar.2014.00191
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 28 December 2015
Date of first compliant Open Access: 28 December 2015
Funder: Engineering and Physical Sciences Research Council (EPSRC)
Grant number: EP/K035193/1 (EPSRC)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us