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Alcohol consumption and cognitive performance : a Mendelian randomization study
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(2014) Alcohol consumption and cognitive performance : a Mendelian randomization study. Addiction, Volume 109 (Number 9). pp. 1462-1471. doi:10.1111/add.12568 ISSN 0965-2140.
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Official URL: http://dx.doi.org/10.1111/add.12568
Abstract
Aims
To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function.
Design
Mendelian randomization using a genetic variant related to alcohol intake (ADH1B rs1229984) was used to obtain unbiased estimates of the association between alcohol intake and cognitive performance.
Setting
Europe.
Participants
More than 34 000 adults.
Measurements
Any versus no alcohol intake and units of intake in the previous week was measured by questionnaire. Cognitive function was assessed in terms of immediate and delayed word recall, verbal fluency and processing speed.
Findings
Having consumed any versus no alcohol was associated with higher scores by 0.17 standard deviations (SD) [95% confidence interval (CI) = 0.15, 0.20] for immediate recall, 0.17 SD (95% CI = 0.14, 0.19) for delayed recall, 0.17 SD (95% CI = 0.14, 0.19) for verbal fluency and 0.12 SD (95% CI = 0.09, 0.15) for processing speed. The minor allele of rs1229984 was associated with reduced odds of consuming any alcohol (odds ratio = 0.87; 95% CI = 0.80, 0.95; P = 0.001; R2 = 0.1%; F-statistic = 47). In Mendelian randomization analysis, the minor allele was not associated with any cognitive test score, and instrumental variable analysis suggested no causal association between alcohol consumption and cognition: −0.74 SD (95% CI = −1.88, 0.41) for immediate recall, −1.09 SD (95% CI = −2.38, 0.21) for delayed recall, −0.63 SD (95% CI = −1.78, 0.53) for verbal fluency and −0.16 SD (95% CI = −1.29, 0.97) for processing speed.
Conclusions
The Mendelian randomization analysis did not provide strong evidence of a causal association between alcohol consumption and cognitive ability.
| Item Type: | Journal Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Addiction | ||||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||||
| ISSN: | 0965-2140 | ||||||||||
| Official Date: | 2014 | ||||||||||
| Dates: |
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| Volume: | Volume 109 | ||||||||||
| Number: | Number 9 | ||||||||||
| Page Range: | pp. 1462-1471 | ||||||||||
| DOI: | 10.1111/add.12568 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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