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Are cardiovascular trial results systematically different between North America and Europe? A study based on intra-meta-analysis comparisons

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Bowater, Russell J., Hartley, Louise and Lilford, Richard (2015) Are cardiovascular trial results systematically different between North America and Europe? A study based on intra-meta-analysis comparisons. Archives of Cardiovascular Diseases, 108 (1). doi:10.1016/j.acvd.2014.03.005 ISSN 1875-2136.

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Official URL: http://dx.doi.org/10.1016/j.acvd.2014.03.005

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Abstract

Summary
Background
It is often assumed that differences in the efficacy of treatments between countries (or regions) will be neither negligible nor minor and therefore cannot be overlooked when assessing the potential benefit of treatments in one country (or region) on the basis of trials conducted in another country (or region).

Aim
To assess differences in the results of cardiovascular trials between Europe and North America on the basis of data from an extensive collection of trials.

Methods
A systematic search was conducted of Medline (from the year 2005 to 2008) and the Cochrane Library (from 2000 to 2008) for all meta-analyses of randomized controlled trials aimed at treating and preventing cardiovascular disease. Within each meta-analysis that satisfied given criteria, trial results were compared between Europe and North America with respect to a fatal and/or non-fatal endpoint by forming separate estimates of treatment efficacy for each of these continents.

Results
The literature search found 59 meta-analyses that satisfied all the inclusion criteria. For most meta-analyses, it was the case that relative to the control, the intervention was more favoured in trials conducted in Europe than in North America with regard to both fatal endpoints (28 out of 43 meta-analyses) and non-fatal endpoints (28 out of 40 meta-analyses). However, it was only with regard to non-fatal endpoints that this imbalance turned out to be statistically significant at the 5% level (P = 0.017). Also, the lack of statistically significant differences in trial results between Europe and North America within individual meta-analyses meant that it was not possible to determine for which types of intervention these intercontinental differences are likely to be more pronounced than others.

Conclusion
There is some evidence to support the theory that, relative to controls, interventions are more favoured in cardiovascular trials conducted in Europe than in North America, when treatment efficacy is measured in terms of a non-fatal endpoint. However, the overall support for systematic differences in cardiovascular trial results between Europe and North America is weak, which may be surprising given the amount of data collected.

Item Type: Journal Article
Alternative Title: Est-ce que les résultats des essais en pathologie cardiovasculaire diffèrent systématiquement entre l’Amérique du Nord et l’Europe ? Une étude basée sur des comparaisons à l’intérieur de méta-analyses
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Archives of Cardiovascular Diseases
Publisher: Elsevier Masson
ISSN: 1875-2136
Official Date: January 2015
Dates:
DateEvent
January 2015Published
2 July 2014Available
Volume: 108
Number: 1
DOI: 10.1016/j.acvd.2014.03.005
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)

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