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Artificial neural networks in hard tissue engineering : another look at age-dependence of trabecular bone properties in osteoarthritis
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Shaikhina, Torgyn, Khovanova, N. A. and Mallick, Kajal (2014) Artificial neural networks in hard tissue engineering : another look at age-dependence of trabecular bone properties in osteoarthritis. In: International Conference on Biomedical and Health Informatics, Valencia, Spain, 1-4 Jun 2014. Published in: International Conference on Biomedical and Health Informatics (BHI), 2014 IEEE-EMBS pp. 622-625. doi:10.1109/BHI.2014.6864441
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Official URL: http://dx.doi.org/10.1109/BHI.2014.6864441
Abstract
Artificial Neural Network (ANN) model has been developed to correlate age of severely osteoarthritic male and female specimens with key mechanical and structural characteristics of their trabecular bone. The complex interdependency between age, gender, compressive strength, porosity, morphology and level of interconnectivity was analysed in multi-dimensional space using a two-layer feedforward ANN. Trained by Levenberg-Marquardt back propagation algorithm, the ANN achieved regression factor of R = 96.3% between the predicted and target age when optimised for the experimental dataset. Results indicate a strong correlation of the 5-dimensional vector of physical properties of the bone with the age of the specimens. The inverse problem of estimating compressive strength as the key bone fracture risk was also investigated. The outcomes yield correlation between predicted and target compressive strength with the regression factor of R = 97.4%. Within the limitations of the input data set, the ANNs provide robust predictive models for hard tissue engineering decision support.
Item Type: | Conference Item (Paper) | ||||
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Subjects: | Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||
Library of Congress Subject Headings (LCSH): | Neural networks (Computer science), Osteoarthritis, Older people -- Care | ||||
Journal or Publication Title: | International Conference on Biomedical and Health Informatics (BHI), 2014 IEEE-EMBS | ||||
Publisher: | IEEE Computer Society | ||||
Book Title: | IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI) | ||||
Official Date: | 2014 | ||||
Dates: |
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Page Range: | pp. 622-625 | ||||
DOI: | 10.1109/BHI.2014.6864441 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Date of first compliant deposit: | 28 December 2015 | ||||
Date of first compliant Open Access: | 28 December 2015 | ||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC) | ||||
Grant number: | EP/K02504X/1 (EPSRC) | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | International Conference on Biomedical and Health Informatics | ||||
Type of Event: | Conference | ||||
Location of Event: | Valencia, Spain | ||||
Date(s) of Event: | 1-4 Jun 2014 |
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