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Synthesis of the antimalarial API artemether in a flow reactor
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Yaseneva, Polina, Plaza, Dorota, Fan, Xiaolei, Loponov, Konstantin and Lapkin, Alexei (2015) Synthesis of the antimalarial API artemether in a flow reactor. Catalysis Today, Volume 239 . pp. 90-96. doi:10.1016/j.cattod.2014.04.014
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Official URL: http://dx.doi.org/10.1016/j.cattod.2014.04.014
Abstract
The earlier developed flow protocol for stoichiometric reduction of an important biologically derived pharmaceutical precursor, artemisinin, to dihydroartemisinin was extended to a sequential reaction to produce one of the final APIs, artemether. A highly active heterogeneous catalyst was found for the etherification reaction. The use of QuadraSil catalyst allows to eliminate one step of reaction workup. A comparative Life Cycle Assessment of both reactions has shown advantages of the flow process over the optimized literature batch protocols. Results of LCA highlight the significance of solvents in pharmaceuticals manufacture and the advantage of flow technology, enabling small solvent inventories to be used.
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Science > Engineering | ||||||||||
| Journal or Publication Title: | Catalysis Today | ||||||||||
| Publisher: | Elsevier BV | ||||||||||
| ISSN: | 0920-5861 | ||||||||||
| Official Date: | 1 January 2015 | ||||||||||
| Dates: |
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| Volume: | Volume 239 | ||||||||||
| Page Range: | pp. 90-96 | ||||||||||
| DOI: | 10.1016/j.cattod.2014.04.014 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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