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Stabilization of amino acid derived diblock copolymer micelles through favorable D:L side chain interactions
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Skey, Jared, Hansell, Claire F. and O'Reilly, Rachel K. (2010) Stabilization of amino acid derived diblock copolymer micelles through favorable D:L side chain interactions. Macromolecules, Vol.43 (No.3). pp. 1309-1318. doi:10.1021/ma902356u
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Official URL: http://dx.doi.org/10.1021/ma902356u
Abstract
Optically pure N-acryloyl-(D)-leucine methyl ester (D-Leu-OMe) (1) and N-acryloyl-(1)-leucine methyl ester (L-Leu-OMe) (2) were synthesized and studied using infrared spectroscopy and melting point analysis to determine if D-L interactions are preferential relative to D-D or L-L interactions. Reversible addition-fragmentation chain transfer (RAFT) polymerization yielded enantiopure homopolymers of D-Leu-OMe (1) and L-Leu-OMe ester (2). The two enantiopure polymers. 5 and 6. and a 1:1 w/w racemic blend of both polymers were studied using infrared spectroscopy to investigate the intermolecular interactions in the polymeric systems. Poly(tert-butyl acrylate) [P('BuA)] macro chain transfer agents were used to synthesize two diblock copolymers from 1 and 2. respectively. Subsequent deprotection of the P('BuA) block to poly(acrylic acid) (PAA) yielded two chiral amphiphilic diblock copolymers. 7 and 8. Both enantiopure polymers were self-assesmbled separately and then in a 1:1 w/w ratio, and the resulting morphologies characterized using dynamic light scattering, atomic force microscopy, transmission electron miroscopy, and circular dichroism.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology |
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| Divisions: | Faculty of Science > Chemistry | ||||
| Library of Congress Subject Headings (LCSH): | Diblock copolymers, Micelles, Amino acids, Self-assembly (Chemistry), Nanostructures | ||||
| Journal or Publication Title: | Macromolecules | ||||
| Publisher: | American Chemical Society | ||||
| ISSN: | 0024-9297 | ||||
| Official Date: | 9 February 2010 | ||||
| Dates: |
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| Volume: | Vol.43 | ||||
| Number: | No.3 | ||||
| Number of Pages: | 10 | ||||
| Page Range: | pp. 1309-1318 | ||||
| DOI: | 10.1021/ma902356u | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Funder: | Royal Society (Great Britain), Leverhulme Trust (LT), Wellcome Trust (London, England), Engineering and Physical Sciences Research Council (EPSRC), University of Cambridge | ||||
| Grant number: | 055663/Z/9S/Z (WT) |
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