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Biomimetic polymers responsive to a biological signaling molecule : nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles
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Hu, Jinming, Whittaker, Michael R., Duong, Hien, Li, Yang, Boyer, Cyrille and Davis, Thomas P. (2014) Biomimetic polymers responsive to a biological signaling molecule : nitric oxide triggered reversible self-assembly of single macromolecular chains into nanoparticles. Angewandte Chemie International Edition, Volume 53 (Number 30). pp. 7779-7784. doi:10.1002/anie.201403147 ISSN 1433-7851.
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Official URL: http://dx.doi.org/10.1002/anie.201403147
Abstract
Novel nitric oxide (NO) responsive monomers (NAPMA and APUEMA) containing o-phenylenediamine functional groups have been polymerized to form NO-responsive macromolecular chains as truly biomimetic polymers. Upon exposure to NO—a ubiquitous cellular signaling molecule—the NAPMA- and APUEMA-labeled thermoresponsive copolymers exhibited substantial changes in solubility, clearly characterized by tuneable LCST behavior, thereby inducing self-assembly into nanoparticulate structures. Moreover, the NO-triggered self-assembly process in combination with environmentally sensitive fluorescence dyes could be employed to detect and image endogenous NO.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | Angewandte Chemie International Edition | ||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||
ISSN: | 1433-7851 | ||||
Official Date: | 2014 | ||||
Dates: |
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Volume: | Volume 53 | ||||
Number: | Number 30 | ||||
Page Range: | pp. 7779-7784 | ||||
DOI: | 10.1002/anie.201403147 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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