Lapkin, Alexei, Peters, Martina, Greiner, Lasse, Chemat, Smai, Leonhard, Kai, Liauw, Marcel A. and Leitner, Walter. (2010) Screening of new solvents for artemisinin extraction process using ab initio methodology. Green Chemistry, Vol.12 (No.2). pp. 241-251. ISSN 1463-9262

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Abstract

The solubility of artemisinin in a range of conventional and novel solvents was evaluated using the COSMO-RS approach, and verified experimentally as well as against literature data. The computational method was improved by calibrating against a limited set of experimental data, enhancing the accuracy of the calculations. The optimised method was shown to be in reasonable agreement with experimental data; however, lack of reliable experimental data is identified as an issue. Several novel solvents perceived as green alternatives to conventional solvents were targeted and shown to offer good solubility of artemisinin. Extraction from Artemisia annua by carbonate solvents was experimentally verified.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry T Technology > TP Chemical technology
Divisions:	Faculty of Science > Engineering
Library of Congress Subject Headings (LCSH):	Artemisinin, Extraction (Chemistry), Solvent extraction
Journal or Publication Title:	Green Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1463-9262
Official Date:	February 2010
Dates:	Date Event February 2010 Published
Volume:	Vol.12
Number:	No.2
Number of Pages:	11
Page Range:	pp. 241-251
Identifier:	10.1039/b922001a
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), RWTH Aachen University "Tailor Made Fuels from Biomass"
Grant number:	EP/F016182/1 (EPSRC), EXC236 (Aachen)
URI:	http://wrap.warwick.ac.uk/id/eprint/6476

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