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What factors influence concordance with medications? Findings from the UK Asian Diabetes study
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Lloyd, C. E., Mughal, S., Roy, T., Raymond, Neil T., O'Hare, J. Paul, Barnett, A. H. and Bellary, S. (2014) What factors influence concordance with medications? Findings from the UK Asian Diabetes study. Diabetic Medicine, Volume 31 (Number 12). pp. 1600-1609. doi:10.1111/dme.12554
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Official URL: http://dx.doi.org/10.1111/dme.12554
Abstract
Aims
To investigate concordance with medication, as assessed at baseline and at 1- and 2-year follow-up, and to examine factors associated with non-concordance in a UK-resident South-Asian population.
Methods
Data from the UK Asian Diabetes Study were analysed. Concordance with medications was assessed and recorded at three time points during the study. Multiple logistic regression was used to investigate the factors associated with non-concordance; the associations of baseline factors with year 1 concordance and baseline plus year 1 factors with year 2 concordance.
Results
Data for 403 patients from seven practices participating in the UK Asian Diabetes Study were analysed. The numbers of patients who were non-concordant were: 63 (16%) at baseline; 101 (25%) at year 1; and 122 (30%) at year 2. The baseline-measured variables that were significantly associated with year 1 non-concordance included diabetes duration, history of cardiovascular disease, components of the EuroQol quality of life questionnaire, the EQ-5D score, and number of medications prescribed. In multivariable analyses, the most important determinant of year 1 non-concordance was baseline non-concordance: odds ratio 13.6 (95% confidence limits 4.7, 39.9). Number of medications prescribed for blood pressure control was also significant: odds ratio 1.8 (95% confidence limits 1.4, 2.4). Similar results were observed for year 2 non-concordance.
Conclusions
Non-concordance with medications was common and more likely in people prescribed more medications. The current target-driven management of risk factor levels may lead to increasing numbers and doses of medications. Considering the high cost of medications and the implications of poor health behaviours on morbidity and mortality, further investigation of prescribing behaviours and the factors affecting patient concordance are required.
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology |
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| Journal or Publication Title: | Diabetic Medicine | ||||||||||
| Publisher: | Blackwell | ||||||||||
| ISSN: | 0742-3071 | ||||||||||
| Official Date: | December 2014 | ||||||||||
| Dates: |
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| Volume: | Volume 31 | ||||||||||
| Number: | Number 12 | ||||||||||
| Page Range: | pp. 1600-1609 | ||||||||||
| DOI: | 10.1111/dme.12554 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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