Winn, M. (Michael), Goss, Rebecca J. M., Kimura, Ken-ichi and Bugg, Tim (2010) Antimicrobial nucleoside antibiotics targeting cell wall assembly : recent advances in structure-function studies and nucleoside biosynthesis. Natural Product Reports, Vol.27 (No.2). pp. 279-304. ISSN 0265-0568

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Abstract

The quest for new antibiotics, especially those with activity against Gram-negative bacteria, is urgent; however, very few new antibiotics have been marketed in the last 40 years, with this limited number falling into only four new structural classes. Several nucleoside natural product antibiotics target bacterial translocase MraY, involved in the lipid-linked cycle of peptidoglycan biosynthesis, and fungal chitin synthase. Biosynthetic studies on the nikkomycin, caprazamycin and pacidamycin/mureidomycin families are also reviewed.

Item Type:	Journal Item
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology Q Science > QR Microbiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Nucleosides, Anti-infective agents, Bacterial cell walls -- Synthesis, Bacterial diseases -- Treatment
Journal or Publication Title:	Natural Product Reports
Publisher:	Royal Society of Chemistry
ISSN:	0265-0568
Official Date:	2010
Volume:	Vol.27
Number:	No.2
Number of Pages:	26
Page Range:	pp. 279-304
Identification Number:	10.1039/b816215h
Status:	Peer Reviewed
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/6519

Data sourced from Thomson Reuters' Web of Knowledge

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