Sun, Qi, Townsend, Mary K., Okereke, Olivia I., Franco, Oscar H., Hu, Frank B. and Grodstein, Francine. (2010) Physical activity at midlife in relation to successful survival in women at age 70 years or older. Archives of Internal Medicine, Vol.170 (No.2). pp. 194-201. ISSN 0003-9926

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Abstract

Background: Physical activity is associated with reduced risks of chronic diseases and premature death. Whether physical activity is also associated with improved overall health among those who survive to older ages is unclear. Methods: A total of 13 535 Nurses' Health Study participants who were free of major chronic diseases at baseline in 1986 and had survived to age 70 years or older as of the 1995-2001 period made up the study population. We defined successful survival as no history of 10 major chronic diseases or coronary artery bypass graft surgery and no cognitive impairment, physical impairment, or mental health limitations. Results: After multivariate adjustment for covariates, higher physical activity levels at midlife, as measured by metabolic-equivalent tasks, were significantly associated with better odds of successful survival. Significant increases in successful survival were observed beginning at the third quintile of activity: odds ratios (ORs) (95% confidence intervals [CIs]) in the lowest to highest quintiles were 1 [Reference], 0.98 (0.80-1.20), 1.37 (1.13-1.65), 1.34 (1.11-1.61), and 1.99 (1.66-2.38) (P < .001 for trend). Increasing energy expenditure from walking was associated with a similar elevation in odds of successful survival: the ORs (95% CIs) of successful survival across quintiles of walking were 1 [Reference], 0.99 (0.80-1.21), 1.19 (0.97-1.45), 1.50 (1.24-1.82), and 1.47 (1.22-1.79) (P < .001 for trend). Conclusion: These data provide evidence that higher levels of midlife physical activity are associated with exceptional health status among women who survive to older ages and corroborate the potential role of physical activity in improving overall health.

Item Type:	Journal Article
Subjects:	R Medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Archives of Internal Medicine
Publisher:	American Medical Association
ISSN:	0003-9926
Date:	25 January 2010
Volume:	Vol.170
Number:	No.2
Number of Pages:	8
Page Range:	pp. 194-201
Identification Number:	10.1097/OGX.0b013e3181e5a146
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institutes of Health, Boston Obesity Nutrition Research Center, Unilever Corporate Research, Yerby Postdoctoral Fellowship, American Heart Association
Grant number:	AG13482, AG15424, CA40356, DK46200
URI:	http://wrap.warwick.ac.uk/id/eprint/6532

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