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Low serum cartonectin/CTRP3 concentrations in newly diagnosed Type 2 Diabetes Mellitus : in vivo regulation of Cartonectin by glucose
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Ban, Bo, Bai, Bo, Zhang, Manman, Hu, Jiamiao, Ramanjaneya, Manjunath, Tan, Bee K. and Chen, Jing (2014) Low serum cartonectin/CTRP3 concentrations in newly diagnosed Type 2 Diabetes Mellitus : in vivo regulation of Cartonectin by glucose. PLoS One, Volume 9 (Number 11). Article number e112931. doi:10.1371/journal.pone.0112931 ISSN 1932-6203.
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Official URL: http://dx.doi.org/10.1371/journal.pone.0112931
Abstract
Objectives:
Cartonectin is a novel adipokine of the C1q complement/TNF-related protein (CTRP) superfamily, with glucose lowering effects, anti-inflammatory and cardio-protective properties. We sought to investigate circulating cartonectin concentrations in subjects with type 2 diabetes mellitus (T2DM) as well as age and BMI matched control subjects. We also examined the effects of a 2 hour 75 g oral glucose tolerance test (OGTT) on serum cartonectin concentrations in T2DM subjects.
Design
Cross-sectional study [newly diagnosed (first discovery, not on any treatments) T2DM (n = 47) and control (n = 63) subjects]. Serum cartonectin was measured by ELISA.
Results:
Serum cartonectin concentrations were significantly lower in patients with T2DM compared to controls (P<0.05). Furthermore, serum cartonectin was significantly negatively correlated with glucose and CRP, and significantly positively correlated with leptin, in all subjects (n = 110). When subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). There were no significant correlations in T2DM subjects (n = 47). In control subjects (n = 63), serum cartonectin was significantly negatively correlated with CRP, and significantly positively correlated with insulin, HOMA-IR and leptin. However, when subjected to multiple regression analysis, none of these variables were predictive of serum cartonectin (P>0.05). Finally, serum cartonectin concentrations were significantly lower in T2DM subjects after a 2 hour 75 g OGTT (P<0.01).
Conclusions:
Cartonectin may serve as a novel biomarker for the prediction and early diagnosis of T2DM patients. Furthermore, cartonectin and/or pharmacological agents that increase circulating cartonectin levels can represent a new therapeutic field in the treatment of T2DM patients. Further research is needed to clarify these points.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
Library of Congress Subject Headings (LCSH): | Diabetes -- Treatment, Blood sugar -- Analysis | ||||||||
Journal or Publication Title: | PLoS One | ||||||||
Publisher: | Public Library of Science | ||||||||
ISSN: | 1932-6203 | ||||||||
Official Date: | 19 November 2014 | ||||||||
Dates: |
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Volume: | Volume 9 | ||||||||
Number: | Number 11 | ||||||||
Number of Pages: | 5 | ||||||||
Article Number: | Article number e112931 | ||||||||
DOI: | 10.1371/journal.pone.0112931 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 28 December 2015 | ||||||||
Date of first compliant Open Access: | 28 December 2015 | ||||||||
Funder: | Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Provincial Natural Science Foundation of Shandong | ||||||||
Grant number: | 31271243 (NSFC), 81070961 (NSFC), ZR2009CZ006 (PNSFS), ZR2011CM027 (PNSFS) |
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