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Maternal obesity and its relationship with spontaneous and oxytocin-induced contractility of human myometrium in vitro
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Higgins, Claire A., Martin, William, Anderson, Laurie, Blanks, Andrew M., Norman, Jane E., McConnachie, A. and Nelson, S. M. (2010) Maternal obesity and its relationship with spontaneous and oxytocin-induced contractility of human myometrium in vitro. Reproductive Sciences, Vol.17 (No.2). pp. 177-185. doi:10.1177/1933719109349780
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Official URL: http://dx.doi.org/10.1177/1933719109349780
Abstract
Maternal obesity is associated with increased rates of labor induction, dysfunctional labor requiring intrapartum cesarean delivery, and postpartum hemorrhage, implying that maternal obesity has an inhibitory effect on myometrial function. and its ability to respond to oxytocin. This study aimed to use an in vitro model to investigate the relationship between maternal body mass index (BMI) and the ability Of myometrium to contract spontaneously and in response to oxytocin, Linear mixed effects regression modeling was applied to contractile data from 609 strips from 85 women. No correlation was found between maternal BMI and any indices of spontaneous myometrial activity. A single addition of oxytocin increased contractility, however, this was not related to maternal BMI. Similarly, oxytocin concentration-response curves were unrelated to BMI. Overall, the results from this in vitro study suggest that the observed implications of obesity on parturition in vivo cannot be explained by a direct effect on myometrial contractile mechanisms per se.
| Item Type: | Journal Article | ||||
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| Subjects: | R Medicine > RG Gynecology and obstetrics | ||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Reproductive Health ( - until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Reproductive Sciences | ||||
| Publisher: | Sage Publications, Inc. | ||||
| ISSN: | 1933-7191 | ||||
| Official Date: | February 2010 | ||||
| Dates: |
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| Volume: | Vol.17 | ||||
| Number: | No.2 | ||||
| Number of Pages: | 9 | ||||
| Page Range: | pp. 177-185 | ||||
| DOI: | 10.1177/1933719109349780 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Chief Scientists Office Scotland, Ipsen Fund, Clinical Research Fellowship, Gardner Research Training Fellowship, Wellbeing of Women |
Data sourced from Thomson Reuters' Web of Knowledge
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