The Library
Gradual acquisition of immunity to severe malaria with increasing exposure
Tools
Tools
Tools
Griffin, Jamie T., Hollingsworth, T. Déirdre, Reyburn, Hugh, Drakeley, Chris J., Riley, Eleanor and Ghani, Azra C. (2015) Gradual acquisition of immunity to severe malaria with increasing exposure. Proceedings of the Royal Society B : Biological Sciences . pp. 1-8. doi:10.1098/rspb.2014.2657
|
PDF (Creative Commons : Attribution 4.0)
WRAP_20142657.full.pdf - Published Version - Requires a PDF viewer. Download (794Kb) | Preview |
Official URL: http://dx.doi.org/10.1098/rspb.2014.2657
Abstract
Previous analyses have suggested that immunity to non-cerebral severe malaria due to Plasmodium falciparum is acquired after only a few infections, whereas longitudinal studies show that some children experience multiple episodes of severe disease, suggesting that immunity may not be acquired so quickly. We fitted a mathematical model for the acquisition and loss of immunity to severe disease to the age distribution of severe malaria cases stratified by symptoms from a range of transmission settings in Tanzania, combined with data from several African countries on the age distribution and overall incidence of severe malaria. We found that immunity to severe disease was acquired more gradually with exposure than previously thought. The model also suggests that physiological changes, rather than exposure, may alter the symptoms of disease with increasing age, suggesting that a later age at infection would be associated with a higher proportion of cases presenting with cerebral malaria regardless of exposure. This has consequences for the expected pattern of severe disease as transmission changes. Careful monitoring of the decline in immunity associated with reduced transmission will therefore be needed to ensure rebound epidemics of severe and fatal malaria are avoided.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine | ||||||||
| Divisions: | Faculty of Science > Life Sciences (2010- ) Faculty of Science > Mathematics |
||||||||
| Library of Congress Subject Headings (LCSH): | Malaria -- Immunological aspects, Plasmodium falciparum | ||||||||
| Journal or Publication Title: | Proceedings of the Royal Society B : Biological Sciences | ||||||||
| Publisher: | The Royal Society Publishing | ||||||||
| ISSN: | 0962-8452 | ||||||||
| Official Date: | 7 January 2015 | ||||||||
| Dates: |
|
||||||||
| Date of first compliant deposit: | 28 December 2015 | ||||||||
| Number of Pages: | 8 | ||||||||
| Page Range: | pp. 1-8 | ||||||||
| DOI: | 10.1098/rspb.2014.2657 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access | ||||||||
| Funder: | Medical Research Council (Great Britain) (MRC), Imperial College, London, Wellcome Trust (London, England) | ||||||||
| Grant number: | G1002284 (MRC), 9901439 (MRC), 097830/ Z/11/A-C (WT) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
