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Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells
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Suberu, John O., Romero-Canelón, Isolda, Sullivan, Neil F., Lapkin, Alexei and Barker, Guy C. (2014) Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells. ChemMedChem, Volume 9 (Number 12). pp. 2791-2797. doi:10.1002/cmdc.201402285 ISSN 1860-7179.
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Official URL: http://dx.doi.org/10.1002/cmdc.201402285
Abstract
In parts of Africa and Asia, self-medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency than artemisinin alone against both chloroquine-sensitive and -resistant parasites. In this study, in vitro tests of the infusion in MCF7 cells showed high IC50 values (>200 μM). The combination of artemisinin and 3-caffeoylquinic acid (3CA), two major components in the extract, was strongly antagonistic and gave a near total loss of cytotoxicity for artemisinin. We observed that the interaction of 3CAs with another cytotoxic compound, cisplatin, showed potentiation of activity by 2.5-fold. The chelation of cellular iron by 3CA is hypothesized as a possible explanation for the loss of artemisinin activity.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QK Botany R Medicine > RV Botanic, Thomsonian, and eclectic medicine S Agriculture > SB Plant culture |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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Library of Congress Subject Headings (LCSH): | Artemisia, Artemisinin, Chlorogenic acid, Cisplatin, Breast -- Cancer | ||||||||
Journal or Publication Title: | ChemMedChem | ||||||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||
ISSN: | 1860-7179 | ||||||||
Official Date: | December 2014 | ||||||||
Dates: |
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Volume: | Volume 9 | ||||||||
Number: | Number 12 | ||||||||
Number of Pages: | 7 | ||||||||
Page Range: | pp. 2791-2797 | ||||||||
DOI: | 10.1002/cmdc.201402285 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 28 December 2015 | ||||||||
Date of first compliant Open Access: | 28 December 2015 | ||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), SensaPharm Ltd., Technology Strategy Board (Great Britain) |
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