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Role and regulation of kinesin-8 motors through the cell cycle
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Messin, Liam J. and Millar, Jonathan B. A. (2014) Role and regulation of kinesin-8 motors through the cell cycle. Systems and synthetic biology, Volume 8 (Number 3). pp. 205-213. doi:10.1007/s11693-014-9140-z ISSN 1872-5325.
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Official URL: http://dx.doi.org/10.1007/s11693-014-9140-z
Abstract
Members of the kinesin-8 motor family play a central role in controlling microtubule length throughout the eukaryotic cell cycle. Inactivation of kinesin-8 causes defects in cell polarity during interphase and astral and mitotic spindle length, metaphase chromosome alignment, timing of anaphase onset and accuracy of chromosome segregation. Although the biophysical mechanism by which kinesin-8 molecules influence microtubule dynamics has been studied extensively in a variety of species, a consensus view has yet to emerge. One reason for this might be that some members of the kinesin-8 family can associate to other microtubule-associated proteins, cell cycle regulatory proteins and other kinesin family members. In this review we consider how cell cycle specific modification and its association to other regulatory proteins may modulate the function of kinesin-8 to enable it to function as a master regulator of microtubule dynamics.
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Systems and synthetic biology | ||||||||||
| Publisher: | Springer | ||||||||||
| ISSN: | 1872-5325 | ||||||||||
| Official Date: | September 2014 | ||||||||||
| Dates: |
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| Volume: | Volume 8 | ||||||||||
| Number: | Number 3 | ||||||||||
| Page Range: | pp. 205-213 | ||||||||||
| DOI: | 10.1007/s11693-014-9140-z | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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