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Review article : next generation diagnostic modalities in gastroenterology : gas phase volatile compound biomarker detection
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Arasaradnam, Ramesh P., Covington, James A., Harmston, Christopher and Nwokolo, Chuka U. (2014) Review article : next generation diagnostic modalities in gastroenterology : gas phase volatile compound biomarker detection. Alimentary Pharmacology & Therapeutics, Volume 39 (Number 8). pp. 780-789. doi:10.1111/apt.12657
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Official URL: http://dx.doi.org/10.1111/apt.12657
Abstract
Background
The detection of airborne gas phase biomarkers that emanate from biological samples like urine, breath and faeces may herald a new age of non-invasive diagnostics. These biomarkers may reflect status in health and disease and can be detected by humans and other animals, to some extent, but far more consistently with instruments. The continued advancement in micro and nanotechnology has produced a range of compact and sophisticated gas analysis sensors and sensor systems, focussed primarily towards environmental and security applications. These instruments are now increasingly adapted for use in clinical testing and with the discovery of new gas volatile compound biomarkers, lead naturally to a new era of non-invasive diagnostics.
Aim
To review current sensor instruments like the electronic nose (e-nose) and ion mobility spectroscopy (IMS), existing technology like gas chromatography-mass spectroscopy (GC-MS) and their application in the detection of gas phase volatile compound biomarkers in medicine – focussing on gastroenterology.
Methods
A systematic search on Medline and Pubmed databases was performed to identify articles relevant to gas and volatile organic compounds.
Results
E-nose and IMS instruments achieve sensitivities and specificities ranging from 75 to 92% in differentiating between inflammatory bowel disease, bile acid diarrhoea and colon cancer from controls. For pulmonary disease, the sensitivities and specificities exceed 90% in differentiating between pulmonary malignancy, pneumonia and obstructive airways disease. These sensitivity levels also hold true for diabetes (92%) and bladder cancer (90%) when GC-MS is combined with an e-nose.
Conclusions
The accurate reproducible sensing of volatile organic compounds (VOCs) using portable near-patient devices is a goal within reach for today's clinicians.
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Science > Engineering Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Alimentary Pharmacology & Therapeutics | ||||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||||
| ISSN: | 0269-2813 | ||||||||||
| Official Date: | April 2014 | ||||||||||
| Dates: |
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| Volume: | Volume 39 | ||||||||||
| Number: | Number 8 | ||||||||||
| Page Range: | pp. 780-789 | ||||||||||
| DOI: | 10.1111/apt.12657 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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