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Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines
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Koran, Mary Ellen, Thornton-Wells, Tricia A., Jahanshad, Neda, Glahn, David C., Thompson, Paul M., Blangero, John, Nichols, Thomas E., Kochunov, Peter and Landman, Bennett A. (2014) Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines. Journal of Medical Imaging , Volume 1 (Number 1). Article number 014005. doi:10.1117/1.JMI.1.1.014005
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Official URL: http://dx.doi.org/10.1117/1.JMI.1.1.014005
Abstract
Imaging genetics is an emerging methodological field that combines genetic information with medical imaging-derived metrics to understand how genetic factors impact observable phenotypes. In order for a trait to be a reasonable phenotype in an imaging genetics study, it must be heritable: at least some proportion of its variance must be due to genetic influences. The Sequential Oligogenic Linkage Analysis Routines (SOLAR) imaging genetics software can estimate the heritability of a trait in complex pedigrees. We investigate the ability of SOLAR to accurately estimate heritability and common environmental effects on simulated imaging phenotypes in various family structures. We found that heritability is reliably estimated with small family-based studies of 40 to 80 individuals, though subtle differences remain between the family structures. In an imaging application analysis, we found that with 80 subjects in any of the family structures, estimated heritability of white matter fractional anisotropy was biased by <10% for every region of interest. Results from these studies can be used when investigators are evaluating power in planning genetic analyzes.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Science > Statistics Faculty of Science > WMG (Formerly the Warwick Manufacturing Group) |
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| Journal or Publication Title: | Journal of Medical Imaging | ||||
| Publisher: | S P I E - International Society for Optical Engineering | ||||
| ISSN: | 2329-4302 | ||||
| Official Date: | 27 June 2014 | ||||
| Dates: |
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| Volume: | Volume 1 | ||||
| Number: | Number 1 | ||||
| Article Number: | Article number 014005 | ||||
| DOI: | 10.1117/1.JMI.1.1.014005 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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