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Replisome components — post-translational modifications and their effects
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Zech, Juergen and Dalgaard, Jacob Z. (2014) Replisome components — post-translational modifications and their effects. Seminars in Cell & Developmental Biology, Volume 30 . pp. 144-153. doi:10.1016/j.semcdb.2014.03.026 ISSN 1084-9521.
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2014.03.026
Abstract
The process of DNA replication is highly regulated, but at the same time very dynamic. Once S-phase is initiated and replication elongation is occurring, the cells are committed to complete replication in order to ensure genome stability and survival. Many pathways exist to resolve situations where normal replisome progression is not possible. It is becoming more and more evident that post-translational modifications of replisome components play a key role in regulating these pathways which ensure fork progression. Here we review the known modifications of the progressing replisome and how these modifications are thought to affect DNA replication in unperturbed and perturbed S-phases.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Seminars in Cell & Developmental Biology | ||||||
Publisher: | Elsevier Ltd | ||||||
ISSN: | 1084-9521 | ||||||
Official Date: | June 2014 | ||||||
Dates: |
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Volume: | Volume 30 | ||||||
Page Range: | pp. 144-153 | ||||||
DOI: | 10.1016/j.semcdb.2014.03.026 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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