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Decreased plasma chemerin levels in women with gestational diabetes mellitus
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Hare, K. J., Bonde, L., Svare, J. A., Randeva, Harpal S., Asmar, M., Larsen, S., Vilsbøll, T. and Knop, F. K. (2014) Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabetic Medicine, Volume 31 (Number 8). pp. 936-940. doi:10.1111/dme.12436
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Official URL: http://dx.doi.org/10.1111/dme.12436
Abstract
Aims
To evaluate fasting and post-prandial serum chemerin levels in pregnant women with and without gestational diabetes, and again following delivery when normal glucose homeostasis is re-established.
Methods
Chemerin levels were measured in serum from nine women with gestational diabetes, and from eight age- and BMI-matched pregnant women with normal glucose tolerance during two meal tests: in the third trimester and 3–4 months post partum. All women with gestational diabetes re-established normal glucose tolerance after delivery.
Results
Meal intake did not affect serum chemerin levels. The group with gestational diabetes had lower mean serum chemerin levels during the third trimester compared with the group with normal glucose tolerance (28 ± 1.3 vs. 88 ± 3.5 ng/ml, P < 0.0001). In the group with normal glucose tolerance, mean serum chemerin levels decreased significantly post partum to 57 ± 2.8 ng/ml (P = 0.0001), but remained significantly (P = 0.0003) higher than post-partum levels in the group with gestational diabetes (31 ± 1.9 ng/ml), which did not differ significantly from third trimester levels (P = 0.31).
Conclusions
Normal pregnancy is associated with increased circulating chemerin levels, which may act to reduce pregnancy-induced insulin resistance and prevent glucose intolerance. Women with gestational diabetes, however, have severely reduced chemerin levels that remain low after delivery, which may contribute to the insulin resistance, glucose intolerance and high Type 2 diabetes risk associated with gestational diabetes.
| Item Type: | Journal Article | ||||||||||
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| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Diabetic Medicine | ||||||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||||
| ISSN: | 0742-3071 | ||||||||||
| Official Date: | 15 July 2014 | ||||||||||
| Dates: |
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| Volume: | Volume 31 | ||||||||||
| Number: | Number 8 | ||||||||||
| Page Range: | pp. 936-940 | ||||||||||
| DOI: | 10.1111/dme.12436 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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