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Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug
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Zhang, Qiang, Su, Lu, Collins, Jennifer, Chen, Guosong, Wallis, Russell, Mitchell, Daniel A., Haddleton, David M. and Becer, C. Remzi (2014) Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug. Journal of the American Chemical Society, Volume 136 (Number 11). pp. 4325-4332. doi:10.1021/ja4131565 ISSN 0002-7863.
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Official URL: http://dx.doi.org/10.1021/ja4131565
Abstract
A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
Journal or Publication Title: | Journal of the American Chemical Society | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 0002-7863 | ||||||
Official Date: | 25 February 2014 | ||||||
Dates: |
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Volume: | Volume 136 | ||||||
Number: | Number 11 | ||||||
Page Range: | pp. 4325-4332 | ||||||
DOI: | 10.1021/ja4131565 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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