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Developing a core outcome set for hip fracture trials
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Haywood, Kirstie L., Griffin, Xavier L., Achten, Juul and Costa, Matthew L. (2014) Developing a core outcome set for hip fracture trials. The Bone & Joint Journal, Volume 96-B (Number 8). pp. 1016-1023. doi:10.1302/0301-620X.96B8.33766 ISSN 2049-4394.
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Official URL: http://dx.doi.org/10.1302/0301-620X.96B8.33766
Abstract
The lack of a consensus for core health outcomes that should be reported in clinical research has hampered study design and evidence synthesis. We report a United Kingdom consensus for a core outcome set (COS) for clinical trials of patients with a hip fracture. We adopted a modified nominal group technique to derive consensus on 1) which outcome domains should be measured, and 2) methods of assessment. Participants reflected a diversity of perspectives and experience. They received an evidence synthesis and postal questionnaire in advance of the consensus meeting, and ranked the importance of candidate domains and the relevance and suitability of short-listed measures. During the meeting, pre-meeting source data and questionnaire responses were summarised, followed by facilitated discussion and a final plenary session. A COS was determined using a closed voting system: a 70% consensus was required. Consensus supported a five-domain COS: mortality, pain, activities of daily living, mobility, and health-related quality of life (HRQL). Single-item measures of mortality and mobility (indoor/outdoor walking status) and a generic multi-item measure of HRQL - the EuroQoL EQ-5D - were recommended. These measures should be included as a minimum in all hip fracture trials. Other outcome measures should be added depending on the particular interventions being studied. Cite this article:
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Warwick Research in Nursing > Royal College of Nursing Research Institute (RCN) (- July 2017) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | The Bone & Joint Journal | ||||||||
| Publisher: | British Editorial Society of Bone and Joint Surgery | ||||||||
| ISSN: | 2049-4394 | ||||||||
| Official Date: | August 2014 | ||||||||
| Dates: |
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| Volume: | Volume 96-B | ||||||||
| Number: | Number 8 | ||||||||
| Page Range: | pp. 1016-1023 | ||||||||
| DOI: | 10.1302/0301-620X.96B8.33766 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access |
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