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Elevated serum free light chains predict cardiovascular events in type 2 diabetes
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Bellary, S., Faint, J. M., Assi, L. K., Hutchison, C. A., Harding, S. J., Raymond, Neil T. and Barnett, A. H. (2014) Elevated serum free light chains predict cardiovascular events in type 2 diabetes. Diabetes Care, Volume 37 (Number 7). pp. 2028-2030. doi:10.2337/dc13-2227 ISSN 0149-5992.
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Official URL: http://dx.doi.org/10.2337/dc13-2227
Abstract
OBJECTIVE Elevated polyclonal serum immunoglobulin free light chains (FLCs; combined FLCκ+FLCλ [cFLC]) are associated with adverse clinical outcomes and increased mortality; we investigated cFLC and cardiovascular disease (CVD) events in type 2 diabetes.
RESEARCH DESIGN AND METHODS In a cohort study of 352 south Asian patients with type 2 diabetes, serum cFLC, high-sensitivity C-reactive protein (hsCRP), and standard biochemistry were measured. CVD events over 2 years were recorded and assessed using multiple logistic regression.
RESULTS cFLC levels were elevated significantly in 29 of 352 (8%) patients with CVD events during 2 years of follow-up (50.7 vs. 42.8 mg/L; P = 0.004). In multivariate analysis, elevated cFLC (>57.2 mg/L) was associated with CVD outcomes (odds ratio 3.3 [95% CI 1.3–8.2]; P = 0.012) and remained significant after adjusting for age, albumin-to-creatinine ratio, diabetes duration, or treatment.
CONCLUSIONS cFLC elevation is a novel marker for CVD outcomes in type 2 diabetes that warrants further investigation.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Diabetes Care | ||||
Publisher: | American Diabetes Association | ||||
ISSN: | 0149-5992 | ||||
Official Date: | July 2014 | ||||
Dates: |
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Volume: | Volume 37 | ||||
Number: | Number 7 | ||||
Page Range: | pp. 2028-2030 | ||||
DOI: | 10.2337/dc13-2227 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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