Wellcome Trust Case Control Consortium 2 (Including: Harlaar, Nicole, Meaburn, Emma L., Hayiou-Thomas, Marianna E., Davis, Oliver S. P., Docherty, Sophia, Hanscombe, Ken B., Haworth, Claire M. A., Price, Tom S., Trzaskowski, Maciej, Dale, Philip S. and Plomin, Robert). (2014) Genome-wide association study of receptive language ability of 12-year-olds. Journal of Speech, Language, and Hearing Research, Volume 57 (Number 1). pp. 96-105. doi:10.1044/1092-4388(2013/12-0303)

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Abstract

Purpose:
Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach.

Method:
The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores.

Results: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome ( p < 5 × 10 −8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds.

Conclusions:
These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants.

Item Type:	Journal Article
Subjects:	P Language and Literature > P Philology. Linguistics R Medicine > RJ Pediatrics
Divisions:	Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH):	Language acquisition -- Genetic aspects
Journal or Publication Title:	Journal of Speech, Language, and Hearing Research
Publisher:	American Speech - Language - Hearing Association
ISSN:	1092-4388
Official Date:	February 2014
Dates:	Date Event February 2014 Published 22 April 2013 Available 18 February 2013 Modified 17 September 2012 Submitted
Date of first compliant deposit:	28 December 2015
Volume:	Volume 57
Number:	Number 1
Number of Pages:	10
Page Range:	pp. 96-105
DOI:	10.1044/1092-4388(2013/12-0303)
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Medical Research Council (Great Britain) (MRC), National Institutes of Health (U.S.) (NIH), European Research Council (ERC), Wellcome Trust (London, England), British Academy (BA)
Grant number:	G0901245 (MRC), HD044454 (NIH), HD059215 (NIH), 295366 (ERC), WT088984 (WT), 085475/B/08/Z (WT), 085475/Z/08/Z (WT)

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