Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Genome-wide association study of receptive language ability of 12-year-olds

Tools
- Tools
+ Tools

Wellcome Trust Case Control Consortium 2 (Including: Harlaar, Nicole, Meaburn, Emma L., Hayiou-Thomas, Marianna E., Davis, Oliver S. P., Docherty, Sophia, Hanscombe, Ken B., Haworth, Claire M. A., Price, Tom S., Trzaskowski, Maciej, Dale, Philip S. and Plomin, Robert). (2014) Genome-wide association study of receptive language ability of 12-year-olds. Journal of Speech, Language, and Hearing Research, Volume 57 (Number 1). pp. 96-105. doi:10.1044/1092-4388(2013/12-0303)

[img]
Preview
PDF
WRAP_JSLHR_57_1_96.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution Non-commercial.

Download (46Mb) | Preview
Official URL: http://dx.doi.org/10.1044/1092-4388

Request Changes to record.

Abstract

Purpose:
Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach.

Method:
The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores.

Results: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome ( p < 5 × 10 −8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds.

Conclusions:
These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants.

Item Type: Journal Article
Subjects: P Language and Literature > P Philology. Linguistics
R Medicine > RJ Pediatrics
Divisions: Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH): Language acquisition -- Genetic aspects
Journal or Publication Title: Journal of Speech, Language, and Hearing Research
Publisher: American Speech - Language - Hearing Association
ISSN: 1092-4388
Official Date: February 2014
Dates:
DateEvent
February 2014Published
22 April 2013Available
18 February 2013Modified
17 September 2012Submitted
Date of first compliant deposit: 28 December 2015
Volume: Volume 57
Number: Number 1
Number of Pages: 10
Page Range: pp. 96-105
DOI: 10.1044/1092-4388(2013/12-0303)
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Medical Research Council (Great Britain) (MRC), National Institutes of Health (U.S.) (NIH), European Research Council (ERC), Wellcome Trust (London, England), British Academy (BA)
Grant number: G0901245 (MRC), HD044454 (NIH), HD059215 (NIH), 295366 (ERC), WT088984 (WT), 085475/B/08/Z (WT), 085475/Z/08/Z (WT)

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us