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Common DNA markers can account for more than half of the genetic influence on cognitive abilities
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Wellcome Trust Case Control Consortium 2 (Including: Plomin, Robert, Haworth, Claire M. A., Meaburn, Emma L., Price, Tom S. and Davis, Oliver S. P.). (2013) Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychological Science, Volume 24 (Number 4). pp. 562-568. doi:10.1177/0956797612457952
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Official URL: http://dx.doi.org/10.1177/0956797612457952
Abstract
For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification of individual variants to estimate the total heritability captured by common DNA markers on genotyping arrays. In the same sample of 3,154 pairs of 12-year-old twins, we directly compared twin-study heritability estimates for cognitive abilities (language, verbal, nonverbal, and general) with GCTA estimates captured by 1.7 million DNA markers. We found that DNA markers tagged by the array accounted for .66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology | ||||
| Divisions: | Faculty of Science > Psychology | ||||
| Library of Congress Subject Headings (LCSH): | Cognition -- Genetic aspects, Behavior genetics | ||||
| Journal or Publication Title: | Psychological Science | ||||
| Publisher: | Sage Publications Ltd. | ||||
| ISSN: | 1467-9280 | ||||
| Official Date: | April 2013 | ||||
| Dates: |
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| Date of first compliant deposit: | 28 December 2015 | ||||
| Volume: | Volume 24 | ||||
| Number: | Number 4 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 562-568 | ||||
| DOI: | 10.1177/0956797612457952 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access | ||||
| Funder: | Medical Research Council (Great Britain) (MRC), National Institutes of Health (U.S.) (NIH), Wellcome Trust (London, England), European Research Council (ERC) | ||||
| Grant number: | G0901245 (MRC), HD044454 (NIH), HD046167 (NIH), 085475/B/08/Z (WT), 085475/Z/08/Z (WT), G19/2 (MRC), 295366 (ERC), WT088984 (WT) |
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