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Common DNA markers can account for more than half of the genetic influence on cognitive abilities

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Wellcome Trust Case Control Consortium 2 (Including: Plomin, Robert, Haworth, Claire M. A., Meaburn, Emma L., Price, Tom S. and Davis, Oliver S. P.). (2013) Common DNA markers can account for more than half of the genetic influence on cognitive abilities. Psychological Science, Volume 24 (Number 4). pp. 562-568. doi:10.1177/0956797612457952

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Official URL: http://dx.doi.org/10.1177/0956797612457952

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Abstract

For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification of individual variants to estimate the total heritability captured by common DNA markers on genotyping arrays. In the same sample of 3,154 pairs of 12-year-old twins, we directly compared twin-study heritability estimates for cognitive abilities (language, verbal, nonverbal, and general) with GCTA estimates captured by 1.7 million DNA markers. We found that DNA markers tagged by the array accounted for .66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities.

Item Type: Journal Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH): Cognition -- Genetic aspects, Behavior genetics
Journal or Publication Title: Psychological Science
Publisher: Sage Publications Ltd.
ISSN: 1467-9280
Official Date: April 2013
Dates:
DateEvent
April 2013Published
Volume: Volume 24
Number: Number 4
Number of Pages: 7
Page Range: pp. 562-568
DOI: 10.1177/0956797612457952
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Medical Research Council (Great Britain) (MRC), National Institutes of Health (U.S.) (NIH), Wellcome Trust (London, England), European Research Council (ERC)
Grant number: G0901245 (MRC), HD044454 (NIH), HD046167 (NIH), 085475/B/08/Z (WT), 085475/Z/08/Z (WT), G19/2 (MRC), 295366 (ERC), WT088984 (WT)

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