UNSPECIFIED (2005) Systematic review of randomized controlled trials of atypical antipsychotics and selective serotonin reuptake inhibitors for behavioural problems associated with pervasive developmental disorders. JOURNAL OF PSYCHOPHARMACOLOGY, 19 (5). pp. 521-532. ISSN 0269-8811

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Abstract

A systematic review of randomized controlled trials of the use of atypical antipsychotics and selective serotonin reuptake inhibitors in the treatment of behavioural problems associated with pervasive developmental disorders is reported. A search through both published and unpublished literature, including contacting drug companies and known experts in the field was undertaken. Six trials met the criteria for inclusion in the review. They largely suffer from methodological weaknesses; only two trials had satisfactory methodological quality. The heterogeneity in outcome measurements prevented from conducting a meta-analysis. There is yet no coherent body of data concerning the effects of these medications across all sub-classifications of pervasive developmental disorders, across all age categories, and concerning their medium- and long-term effects, and their effects on quality of life. Atypical antipsychotics and selective serotonin reuptake inhibitors may be of benefit for behavioural problems associated with pervasive developmental disorders. Risperidone has been the best studied among these medications. Atypical antipsychotics appear to have a low risk of extrapyramidal symptoms during short-term treatment. The reviewed trials cannot provide data on the use of selective serotonin reuptake inhibitors in the treatment of children with pervasive developmental disorders. No firm conclusions for clinical practice can be drawn. Larger, well-conducted randomized controlled trials with tong-term follow-up are needed.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RS Pharmacy and materia medica
Journal or Publication Title:	JOURNAL OF PSYCHOPHARMACOLOGY
Publisher:	SAGE PUBLICATIONS LTD
ISSN:	0269-8811
Date:	September 2005
Volume:	19
Number:	5
Number of Pages:	12
Page Range:	pp. 521-532
Identification Number:	10.1177/0269881105056541
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/6587

Data sourced from Thomson Reuters' Web of Knowledge

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