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Visual analysis of geocoded twin data puts nature and nurture on the map
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Davis, Oliver S. P., Haworth, Claire M. A., Lewis, Cathryn M. and Plomin, Robert (2012) Visual analysis of geocoded twin data puts nature and nurture on the map. Molecular Psychiatry, Volume 17 (Number 9). pp. 867-874. doi:10.1038/mp.2012.68
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Official URL: http://dx.doi.org/10.1038/mp.2012.68
Abstract
Twin studies allow us to estimate the relative contributions of nature and nurture to human phenotypes by comparing the resemblance of identical and fraternal twins. Variation in complex traits is a balance of genetic and environmental influences; these influences are typically estimated at a population level. However, what if the balance of nature and nurture varies depending on where we grow up? Here we use statistical and visual analysis of geocoded data from over 6700 families to show that genetic and environmental contributions to 45 childhood cognitive and behavioral phenotypes vary geographically in the United Kingdom. This has implications for detecting environmental exposures that may interact with the genetic influences on complex traits, and for the statistical power of samples recruited for genetic association studies. More broadly, our experience demonstrates the potential for collaborative exploratory visualization to act as a lingua franca for large-scale interdisciplinary research.
| Item Type: | Journal Article | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine | ||||||||||
| Divisions: | Faculty of Science > Psychology | ||||||||||
| Library of Congress Subject Headings (LCSH): | Human behavior -- Genetic aspects, Human beings -- Effect of environment on, Epidemiology | ||||||||||
| Journal or Publication Title: | Molecular Psychiatry | ||||||||||
| Publisher: | Nature Publishing Group | ||||||||||
| ISSN: | 1359-4184 | ||||||||||
| Official Date: | 2012 | ||||||||||
| Dates: |
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| Volume: | Volume 17 | ||||||||||
| Number: | Number 9 | ||||||||||
| Number of Pages: | 8 | ||||||||||
| Page Range: | pp. 867-874 | ||||||||||
| DOI: | 10.1038/mp.2012.68 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | Medical Research Council (Great Britain) (MRC), National Institutes of Health (U.S.) (NIH), Wellcome Trust (London, England), British Academy (BA) | ||||||||||
| Grant number: | G0500079 (MRC), HD44454 (NIH), WT088984 (WT) |
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