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Visual analysis of geocoded twin data puts nature and nurture on the map

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Davis, Oliver S. P., Haworth, Claire M. A., Lewis, Cathryn M. and Plomin, Robert (2012) Visual analysis of geocoded twin data puts nature and nurture on the map. Molecular Psychiatry, Volume 17 (Number 9). pp. 867-874. doi:10.1038/mp.2012.68

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Official URL: http://dx.doi.org/10.1038/mp.2012.68

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Abstract

Twin studies allow us to estimate the relative contributions of nature and nurture to human phenotypes by comparing the resemblance of identical and fraternal twins. Variation in complex traits is a balance of genetic and environmental influences; these influences are typically estimated at a population level. However, what if the balance of nature and nurture varies depending on where we grow up? Here we use statistical and visual analysis of geocoded data from over 6700 families to show that genetic and environmental contributions to 45 childhood cognitive and behavioral phenotypes vary geographically in the United Kingdom. This has implications for detecting environmental exposures that may interact with the genetic influences on complex traits, and for the statistical power of samples recruited for genetic association studies. More broadly, our experience demonstrates the potential for collaborative exploratory visualization to act as a lingua franca for large-scale interdisciplinary research.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Science > Psychology
Library of Congress Subject Headings (LCSH): Human behavior -- Genetic aspects, Human beings -- Effect of environment on, Epidemiology
Journal or Publication Title: Molecular Psychiatry
Publisher: Nature Publishing Group
ISSN: 1359-4184
Official Date: 2012
Dates:
DateEvent
2012Published
9 April 2012Accepted
5 March 2012Updated
7 November 2011Submitted
Volume: Volume 17
Number: Number 9
Number of Pages: 8
Page Range: pp. 867-874
DOI: 10.1038/mp.2012.68
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Funder: Medical Research Council (Great Britain) (MRC), National Institutes of Health (U.S.) (NIH), Wellcome Trust (London, England), British Academy (BA)
Grant number: G0500079 (MRC), HD44454 (NIH), WT088984 (WT)

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