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Plomin, Robert and Haworth, Claire M. A. (2010) Genetics and intervention research. Perspectives on Psychological Science, Volume 5 (Number 5). pp. 557-563. doi:10.1177/1745691610383513 ISSN 1745-6916.
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Official URL: http://dx.doi.org/ 10.1177/1745691610383513
Abstract
As part of this special section on genetics and behavioral intervention, we discuss the papers by McGue et al. and by Davey Smith. In the second half of our paper, we consider the integration of genetics and intervention research more broadly. The two papers describe ways to use genetic controls to infer causation from correlational ('observational') data without intervention. McGue et al. discuss the use of twins discordant for exposure, which is a variant of the co-twin control method. This method can show that the link between an exposure and outcome is not entirely mediated genetically. Davey Smith discusses a method called Mendelian randomization that uses DNA to draw causal inferences without the need for experimental intervention. Despite the possibilities for using genetic controls to infer causation from correlational data in order to attenuate the need for intervention studies, we are most excited about the opportunities for integrating genetics and intervention research, especially as new DNA technologies make it possible to incorporate genetics in any intervention research.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||
Journal or Publication Title: | Perspectives on Psychological Science | ||||
Publisher: | Sage Publications Inc. | ||||
ISSN: | 1745-6916 | ||||
Official Date: | September 2010 | ||||
Dates: |
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Volume: | Volume 5 | ||||
Number: | Number 5 | ||||
Page Range: | pp. 557-563 | ||||
DOI: | 10.1177/1745691610383513 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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