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Common disorders are quantitative traits
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Plomin, Robert, Haworth, Claire M. A. and Davis, Oliver S. P. (2009) Common disorders are quantitative traits. Nature Reviews Genetics , Volume 10 (Number 12). pp. 872-878. doi:10.1038/nrg2670 ISSN 1471-0056.
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Official URL: http://dx.doi.org/10.1038/nrg2670
Abstract
After drifting apart for 100 years, the two worlds of genetics - quantitative genetics and molecular genetics - are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size. We highlight a polygenic framework, supported by recent GWA research, in which qualitative disorders can be interpreted simply as being the extremes of quantitative dimensions. Research that focuses on quantitative traits - including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||
Journal or Publication Title: | Nature Reviews Genetics | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1471-0056 | ||||
Official Date: | December 2009 | ||||
Dates: |
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Volume: | Volume 10 | ||||
Number: | Number 12 | ||||
Page Range: | pp. 872-878 | ||||
DOI: | 10.1038/nrg2670 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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