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Increasing heritability of BMI and stronger associations with the FTO gene over childhood
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Haworth, Claire M. A., Carnell, Susan, Meaburn, Emma L., Davis, Oliver S. P., Plomin, Robert and Wardle, Jane (2008) Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity, Volume 16 (Number 12). pp. 2663-2668. doi:10.1038/oby.2008.434 ISSN 1930-7381.
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Official URL: http://dx.doi.org/10.1038/oby.2008.434
Abstract
The growing evidence of health risks associated with the rise in childhood obesity adds to the urgency of understanding the determinants of BMI. Twin analyses on repeated assessments of BMI in a longitudinal sample of >7,000 children indicated that the genetic influence on BMI becomes progressively stronger, with heritability increasing from 0.48 at age 4 to 0.78 at age 11. In the same large twin sample, the association between a common variant in the FTO gene and BMI increased in parallel with the rise in heritability, going from R(2) < 0.001 at age 4 to R(2) = 0.01 at age 11. These findings suggest that expression of FTO may become stronger throughout childhood. Increases in heritability may also be due to children increasingly selecting environments correlated with their genetic propensities.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||
Journal or Publication Title: | Obesity | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 1930-7381 | ||||
Official Date: | December 2008 | ||||
Dates: |
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Volume: | Volume 16 | ||||
Number: | Number 12 | ||||
Page Range: | pp. 2663-2668 | ||||
DOI: | 10.1038/oby.2008.434 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) |
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