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Working memory in preterm-born adults : load-dependent compensatory activity of the posterior default mode network
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Daamen, Marcel, Bäuml, Josef G., Scheef, Lukas, Sorg, Christian, Busch, Barbara, Baumann, Nicole, Bartmann, Peter, Wolke, Dieter, Wohlschläger, Afra and Boecker, Henning (2015) Working memory in preterm-born adults : load-dependent compensatory activity of the posterior default mode network. Human Brain Mapping, 36 (3). pp. 1121-1137. doi:10.1002/hbm.22691
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Official URL: http://dx.doi.org/10.1002/hbm.22691
Abstract
Premature birth is associated with an increased risk of cognitive performance deficits that are dependent on working memory (WM) load in childhood. Less clear is whether preterm-born adults show similar WM impairments, or develop compensatory brain mechanisms that help to overcome prematurity-related functional deficits, for example, by a workload-dependent over-recruitment of WM-typical areas, and/or engagement of alternative brain networks. In this functional magnetic resonance imaging study, 73 adults born very preterm and/or with very low birth weight (VP/VLBW) and 73 term-born controls (CON, mean age: 26.5 years) performed a verbal N-Back paradigm with varying workload (0-back, 1-back, 2-back). Generally, both groups showed similar performance accuracy and task-typical patterns of brain activations (especially in fronto-cingulo-parietal, thalamic, and cerebellar areas) and deactivations (especially in mesial frontal and parietal aspects of the default mode network [DMN]). However, VP/VLBW adults showed significantly stronger deactivations (P < 0.05, cluster-level corrected) than CON in posterior DMN regions, including right ventral precuneus, and right parahippocampal areas (with adjacent cerebellar areas), which were specific for the most demanding 2-back condition. Consistent with a workload-dependent effect, VP/VLBW adults with stronger deactivations (1-back > 2-back) in the parahippocampal/cerebellar cluster also presented a greater slowing of response latencies with increasing WM load (2-back > 1-back), indicative of higher effort. In conclusion, VP/VLBW adults recruited similar anatomical networks as controls during N-back performance, but showed an enhanced suppression of posterior DMN regions during higher workload, which may reflect a temporary suppression of stimulus-independent thoughts that helps to maintain adequate task performance with increasing attentional demands.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | B Philosophy. Psychology. Religion > BF Psychology | ||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Short-term memory in children, Premature infants | ||||||||||
| Journal or Publication Title: | Human Brain Mapping | ||||||||||
| Publisher: | John Wiley and Sons | ||||||||||
| ISSN: | 1065-9471 | ||||||||||
| Official Date: | March 2015 | ||||||||||
| Dates: |
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| Volume: | 36 | ||||||||||
| Number: | 3 | ||||||||||
| Number of Pages: | 17 | ||||||||||
| Page Range: | pp. 1121-1137 | ||||||||||
| DOI: | 10.1002/hbm.22691 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||
| Funder: | Germany. Bundesministerium für Bildung und Forschung (BMBF), Technische Universität München. Kommission für Klinische Forschung | ||||||||||
| Grant number: | BMBF 01ER0801 (BMBF), BMBF 01EV0710 (BMBF), BMBF 01ER0803 (BMBF) |
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