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Screening strategies in surveillance and control of methicillin-resistant Staphylococcus aureus (MRSA)
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Robotham, Julie, Jenkins, D. R. and Medley, Graham (2006) Screening strategies in surveillance and control of methicillin-resistant Staphylococcus aureus (MRSA). Epidemiology and Infection, Vol.135 (No.2). pp. 328-342. doi:10.1017/S095026880600687X ISSN 0950-2688.
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Official URL: http://dx.doi.org/10.1017/S095026880600687X
Abstract
With reports of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) continuing to increase and therapeutic options decrease, infection control methods are of increasing importance. Here we investigate the relationship between surveillance and infection control. Surveillance plays two roles with respect to control: it allows detection of infected/colonized individuals necessary for their removal from the general population, and it allows quantification of control success. We develop a stochastic model of MRSA transmission dynamics exploring the effects of two screening strategies in an epidemic setting: random and on admission. We consider both hospital and community populations and include control and surveillance in a single framework. Random screening was more efficient at hospital surveillance and allowed nosocomial control, which also prevented epidemic behaviour in the community. Therefore, random screening was the more effective control strategy for both the hospital and community populations in this setting. Surveillance strategies have significant impact on both ascertainment of infection prevalence and its control.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QR Microbiology | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) | ||||
Library of Congress Subject Headings (LCSH): | Staphylococcus aureus, Methicillin resistance, Drug resistance in microorganisms, Public health surveillance -- Great Britain, Communicable diseases -- Transmission -- Mathematical models, Stochastic models | ||||
Journal or Publication Title: | Epidemiology and Infection | ||||
Publisher: | Cambridge University Press | ||||
ISSN: | 0950-2688 | ||||
Official Date: | 13 July 2006 | ||||
Dates: |
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Volume: | Vol.135 | ||||
Number: | No.2 | ||||
Page Range: | pp. 328-342 | ||||
DOI: | 10.1017/S095026880600687X | ||||
Status: | Peer Reviewed | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||
Grant number: | DTA Studentship (BBSRC) |
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