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Neurobiological and behavioural studies of affective instability in clinical populations : a systematic review

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Broome, Matthew R., He, Zhimin, Iftikhar, Mashal, Eyden, Julie and Marwaha, Steven (2015) Neurobiological and behavioural studies of affective instability in clinical populations : a systematic review. Neuroscience & Biobehavioral Reviews, 51 . pp. 243-254. doi:10.1016/j.neubiorev.2015.01.021

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Official URL: http://dx.doi.org/10.1016/j.neubiorev.2015.01.021

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Abstract

Objectives
To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations.

Data sources
A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included.

Review methods
Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised.

Results
Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder.

Conclusions
The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development.

Item Type: Journal Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Science > Psychology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Affective disorders, Amygdaloid body
Journal or Publication Title: Neuroscience & Biobehavioral Reviews
Publisher: Pergamon
ISSN: 0149-7634
Official Date: April 2015
Dates:
DateEvent
April 2015Published
4 February 2015Available
26 January 2015Accepted
4 August 2014Submitted
Volume: 51
Page Range: pp. 243-254
DOI: 10.1016/j.neubiorev.2015.01.021
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: National Institute for Health Research (Great Britain). Mental Health Research Network (NIHR)

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