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Neurobiological and behavioural studies of affective instability in clinical populations : a systematic review
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Broome, Matthew R., He, Zhimin, Iftikhar, Mashal, Eyden, Julie and Marwaha, Steven (2015) Neurobiological and behavioural studies of affective instability in clinical populations : a systematic review. Neuroscience & Biobehavioral Reviews, 51 . pp. 243-254. doi:10.1016/j.neubiorev.2015.01.021
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Official URL: http://dx.doi.org/10.1016/j.neubiorev.2015.01.021
Abstract
Objectives
To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations.
Data sources
A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included.
Review methods
Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations. Studies were selected, data were extracted and quality was appraised.
Results
Twenty-nine studies were included, 6 of which were review studies (one a meta-analysis) and 23 of which were primary studies, across a wide variety of disorders including ADHD, bipolar affective disorder, schizophrenia, severe mood dysregulation, major depression, and borderline personality disorder.
Conclusions
The bulk of the studies converge on the role of the amygdala, particularly in borderline personality disorders, and how it connects with other areas of the brain. Future research needs to extend these findings across diagnoses and development.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science > Psychology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Affective disorders, Amygdaloid body | ||||||||||
| Journal or Publication Title: | Neuroscience & Biobehavioral Reviews | ||||||||||
| Publisher: | Pergamon | ||||||||||
| ISSN: | 0149-7634 | ||||||||||
| Official Date: | April 2015 | ||||||||||
| Dates: |
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| Volume: | 51 | ||||||||||
| Page Range: | pp. 243-254 | ||||||||||
| DOI: | 10.1016/j.neubiorev.2015.01.021 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||
| Funder: | National Institute for Health Research (Great Britain). Mental Health Research Network (NIHR) |
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