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Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis
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Lowery, Richard, Gibson, Matthew I., Thompson, Richard C. and Fullam, Elizabeth (2015) Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis. Chemical communications, 51 (23). pp. 4838-4841. doi:10.1039/c4cc09588j
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Official URL: http://dx.doi.org/10.1039/C4CC09588J
Abstract
Understanding and probing small molecule uptake in cells is challenging, requiring sterically large chemical labels, or radioactive isotopes. Here, the uptake of deuterated sugars by Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis, has been investigated using ion-beam (nuclear reaction) analysis demonstrating a new technique for label-free nutrient acquisition measurement.
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QR Microbiology | ||||||||||
| Divisions: | Faculty of Science > Chemistry Faculty of Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Tuberculosis -- Microbiology | ||||||||||
| Journal or Publication Title: | Chemical communications | ||||||||||
| Publisher: | Royal Society of Chemistry | ||||||||||
| ISSN: | 1359-7345 | ||||||||||
| Official Date: | 21 March 2015 | ||||||||||
| Dates: |
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| Volume: | 51 | ||||||||||
| Number: | 23 | ||||||||||
| Number of Pages: | 4 | ||||||||||
| Page Range: | pp. 4838-4841 | ||||||||||
| DOI: | 10.1039/c4cc09588j | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access | ||||||||||
| Funder: | Wellcome Trust (London, England), Advantage West Midlands (AWM), European Regional Development Fund (ERDF), Engineering and Physical Sciences Research Council (EPSRC), Birmingham Science City, Higher Education Funding Council for England (HEFCE), Royal Society (Great Britain) | ||||||||||
| Grant number: | 104193/Z/14/Z (RS) |
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