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Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease
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Rabbani, Naila and Thornalley, Paul J. (2015) Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease. Biochemical and Biophysical Research Communications, 458 (2). pp. 221-226. doi:10.1016/j.bbrc.2015.01.140
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Official URL: http://dx.doi.org/10.1016/j.bbrc.2015.01.140
Abstract
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biochemical and Biophysical Research Communications | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 0006-291X | ||||||||
| Official Date: | 6 March 2015 | ||||||||
| Dates: |
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| Volume: | 458 | ||||||||
| Number: | 2 | ||||||||
| Page Range: | pp. 221-226 | ||||||||
| DOI: | 10.1016/j.bbrc.2015.01.140 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access |
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