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Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

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Rabbani, Naila and Thornalley, Paul J. (2015) Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease. Biochemical and Biophysical Research Communications, 458 (2). pp. 221-226. doi:10.1016/j.bbrc.2015.01.140 ISSN 0006-291X.

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Official URL: http://dx.doi.org/10.1016/j.bbrc.2015.01.140

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Abstract

Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents.

Item Type: Journal Article
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title: Biochemical and Biophysical Research Communications
Publisher: Elsevier
ISSN: 0006-291X
Official Date: 6 March 2015
Dates:
DateEvent
6 March 2015Published
7 February 2015Published
25 January 2015Submitted
Volume: 458
Number: 2
Page Range: pp. 221-226
DOI: 10.1016/j.bbrc.2015.01.140
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)

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