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Single-cell mechanics and calcium signalling in organotypic slices of human myometrium
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Loftus, Fiona C., Richardson, Magnus J. E. and Shmygol, Anatoly (2015) Single-cell mechanics and calcium signalling in organotypic slices of human myometrium. Journal of Biomechanics, 48 (9). pp. 620-624. doi:10.1016/j.jbiomech.2015.01.046 ISSN 0021-9290.
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Official URL: http://dx.doi.org/10.1016/j.jbiomech.2015.01.046
Abstract
The information that connects genotypes and phenotypes is essentially embedded in research articles written in natural language. To facilitate access to this knowledge, we constructed a framework for the curation of the scientific literature studying the molecular mechanisms that control leaf growth and development in Arabidopsis thaliana (Arabidopsis). Standard structured statements, called relations, were designed to capture diverse data types, including phenotypes and gene expression linked to genotype description, growth conditions, genetic and molecular interactions, and details about molecular entities. Relations were then annotated from the literature, defining the relevant terms according to standard biomedical ontologies. This curation process was supported by a dedicated graphical user interface, called Leaf Knowtator. A total of 283 primary research articles were curated by a community of annotators, yielding 9947 relations monitored for consistency and over 12,500 references to Arabidopsis genes. This information was converted into a relational database (KnownLeaf) and merged with other public Arabidopsis resources relative to transcriptional networks, protein–protein interaction, gene co-expression, and additional molecular annotations. Within KnownLeaf, leaf phenotype data can be searched together with molecular data originating either from this curation initiative or from external public resources. Finally, we built a network (LeafNet) with a portion of the KnownLeaf database content to graphically represent the leaf phenotype relations in a molecular context, offering an intuitive starting point for knowledge mining. Literature curation efforts such as ours provide high quality structured information accessible to computational analysis, and thereby to a wide range of applications.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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Library of Congress Subject Headings (LCSH): | Myometrium, Calcium ions, Oxytocin -- Research | ||||||||
Journal or Publication Title: | Journal of Biomechanics | ||||||||
Publisher: | Pergamon Press | ||||||||
ISSN: | 0021-9290 | ||||||||
Official Date: | June 2015 | ||||||||
Dates: |
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Volume: | 48 | ||||||||
Number: | 9 | ||||||||
Number of Pages: | 5 | ||||||||
Page Range: | pp. 620-624 | ||||||||
DOI: | 10.1016/j.jbiomech.2015.01.046 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 29 December 2015 | ||||||||
Date of first compliant Open Access: | 29 December 2015 | ||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||||
Grant number: | D016630/1 |
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