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Protecting the pipeline of science : openness, scientific methods and the lessons from ticagrelor and the PLATO trial
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Coats, Andrew J. S., Nijjer, Sukhjinder S. and Francis, Darrel P. (2014) Protecting the pipeline of science : openness, scientific methods and the lessons from ticagrelor and the PLATO trial. International Journal of Cardiology, Volume 176 (Number 3). pp. 600-604. doi:10.1016/j.ijcard.2014.05.034 ISSN 0167-5273.
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Official URL: http://dx.doi.org/10.1016/j.ijcard.2014.05.034
Abstract
Ticagrelor, a potent antiplatelet, has been shown to be beneficial in patients with acute coronary syndromes in a randomised controlled trial published in a highly ranked peer reviewed journal. Accordingly it has entered guidelines and has been approved for clinical use by authorities. However, there remains a controversy regarding aspects of the PLATO trial, which are not immediately apparent from the peer-reviewed publications. A number of publications have sought to highlight potential discrepancies, using data available in publicly published documents from the US Food and Drug Administration (FDA) leading to disagreement regarding the value of open science and data sharing. We reflect upon potential sources of bias present in even rigorously performed randomised controlled trials, on whether peer review can establish the presence of bias and the need to constantly challenge and question even accepted data.
Item Type: | Journal Article | ||||||||||
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Divisions: | Administration > University Executive Office | ||||||||||
Journal or Publication Title: | International Journal of Cardiology | ||||||||||
Publisher: | Elsevier Ireland Ltd. | ||||||||||
ISSN: | 0167-5273 | ||||||||||
Official Date: | 20 October 2014 | ||||||||||
Dates: |
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Volume: | Volume 176 | ||||||||||
Number: | Number 3 | ||||||||||
Page Range: | pp. 600-604 | ||||||||||
DOI: | 10.1016/j.ijcard.2014.05.034 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access |
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