The Library
A multinuclear solid state NMR spectroscopic study of the structural evolution of disordered calcium silicate sol–gel biomaterials
Tools
Lin, Zhongje, Jones, Julian R., Hanna, John V. and Smith, Mark E. (2015) A multinuclear solid state NMR spectroscopic study of the structural evolution of disordered calcium silicate sol–gel biomaterials. Physical Chemistry Chemical Physics, Volume 2015 (Number 17). pp. 2540-2549. Phys. Chem. Chem. Phys., 2015,17, 2540-2549. doi:10.1039/c4cp04492d ISSN 1463-9076.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1039/C4CP04492D
Abstract
Disordered sol–gel prepared calcium silicate biomaterials show significant, composition dependent ability to bond with bone. Bone bonding is attributed to rapid hydroxycarbonate apatite (HCA) formation on the glass surface after immersion in body fluid (or implantation). Atomic scale details of the development of the structure of (CaO)x(SiO2)1−x (x = 0.2, 0.3 and 0.5) under heat treatment and subsequent dissolution in simulated body fluid (SBF) are revealed through a multinuclear solid state NMR approach using one-dimensional 17O, 29Si, 31P and 1H. Central to this study is the combination of conventional static and magic angle spinning (MAS) and two-dimensional (2D) triple quantum (3Q) 17O NMR experiments that can readily distinguish and quantify the bridging (BOs) and non-bridging (NBOs) oxygens in the silicate network. Although soluble calcium is present in the sol, the 17O NMR results reveal that the sol–gel produced network structure is initially dominated by BOs after gelation, aging and drying (e.g. at 120 °C), indicating a nanoscale mixture of the calcium salt and a predominantly silicate network. Only once the calcium salt is decomposed at elevated temperatures do the Ca2+ ions become available to break BO. Apatite forming ability in SBF depends strongly on the surface OH and calcium content. The presence of calcium aids HCA formation via promotion of surface hydration and the ready availability of Ca2+ ions. 17O NMR shows the rapid loss of NBOs charge balanced by calcium as it is leached into the SBF. The formation of nanocrystalline, partially ordered HCA can be detected via31P NMR. This data indicates the importance of achieving the right balance of BO/NBO for optimal biochemical response and network properties.
Item Type: | Journal Article | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Journal or Publication Title: | Physical Chemistry Chemical Physics | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1463-9076 | ||||||||||
Official Date: | 28 January 2015 | ||||||||||
Dates: |
|
||||||||||
Volume: | Volume 2015 | ||||||||||
Number: | Number 17 | ||||||||||
Page Range: | pp. 2540-2549 | ||||||||||
Article Number: | Phys. Chem. Chem. Phys., 2015,17, 2540-2549 | ||||||||||
DOI: | 10.1039/c4cp04492d | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Adapted As: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |