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Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite
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McMullan, Mark, Gardiner, Anastasia, Bailey, Kate, Kemen, Eric, Ward, Ben J., Cevik, Volkan, Robert-Seilaniantz, Alexandre, Schultz-Larsen, Torsten, Balmuth, Alexi L., Holub, E. B., Oosterhout, Cock van and Jones, Jonathan D. G. (2015) Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite. eLife, 4 . pp. 1-24. e04550. doi:10.7554/eLife.04550 ISSN 2050-084X.
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Official URL: http://dx.doi.org/10.7554/eLife.04550
Abstract
How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species. By analyzing genome sequence assemblies of five isolates, we show they represent three races that are genetically diverged by ~1%. Despite this divergence, their genomes are mosaic-like, with ~25% being introgressed from other races. Sequential infection experiments show that infection by adapted races enables subsequent infection of hosts by normally non-infecting races. This facilitates introgression and the exchange of effector repertoires, and may enable the evolution of novel races that can undergo clonal population expansion on new hosts. We discuss recent studies on hybridization in other eukaryotes such as yeast, Heliconius butterflies, Darwin's finches, sunflowers and cichlid fishes, and the implications of introgression for pathogen evolution in an agro-ecological environment.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QK Botany | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Albugo candida -- Genetics | ||||||||
| Journal or Publication Title: | eLife | ||||||||
| Publisher: | eLife Sciences Publications Ltd. | ||||||||
| ISSN: | 2050-084X | ||||||||
| Official Date: | 27 February 2015 | ||||||||
| Dates: |
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| Volume: | 4 | ||||||||
| Number of Pages: | 24 | ||||||||
| Page Range: | pp. 1-24 | ||||||||
| Article Number: | e04550 | ||||||||
| DOI: | 10.7554/eLife.04550 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 29 December 2015 | ||||||||
| Date of first compliant Open Access: | 29 December 2015 | ||||||||
| Funder: | European Research Council (ERC), Norwick Research Park, Natural Environment Research Council (Great Britain) (NERC), Danish Agency for Science, Technology and Innovation (DASTI) | ||||||||
| Grant number: | 233376 (ALBUGON) (ERC), NE/H020691 (NERC) | ||||||||
| Adapted As: | |||||||||
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