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Multidrug-resistant tuberculosis in Europe, 2010–2011
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(2015) Multidrug-resistant tuberculosis in Europe, 2010–2011. Emerging Infectious Diseases , Volume 21 (Number 3). pp. 409-416. doi:10.3201/eid2103.141343 ISSN 1080-6059.
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Official URL: http://dx.doi.org/10.3201/eid2103.141343
Abstract
Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non–MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010–2011. A total of 52.4% of MDR TB patients had never been treated for TB, which suggests primary transmission of MDR M. tuberculosis. At initiation of treatment for MDR TB, 59.7% of M. tuberculosis strains tested were resistant to pyrazinamide, 51.1% were resistant to ≥1 second-line drug, 26.6% were resistant to second-line injectable drugs, 17.6% were resistant to fluoroquinolones, and 6.8% were extensively drug resistant. Previous treatment for TB was the strongest risk factor for MDR TB. High levels of primary transmission and advanced resistance to second-line drugs characterize MDR TB cases in Europe.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Emerging Infectious Diseases | ||||
| Publisher: | US Department of Health and Human Services | ||||
| ISSN: | 1080-6059 | ||||
| Official Date: | March 2015 | ||||
| Dates: |
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| Volume: | Volume 21 | ||||
| Number: | Number 3 | ||||
| Page Range: | pp. 409-416 | ||||
| DOI: | 10.3201/eid2103.141343 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Open Access (Creative Commons) |
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